{{Rsnum
|rsid=1532085
|Chromosome=15
|position=58391167
|Orientation=plus
|GMAF=0.4458
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene=LOC102724766
|Gene_s=LOC102724766
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 13.3 | 55.8 | 31.0
| HCB | 22.6 | 47.4 | 29.9
| JPT | 36.3 | 47.8 | 15.9
| YRI | 32.0 | 41.5 | 26.5
| ASW | 26.3 | 38.6 | 35.1
| CHB | 22.6 | 47.4 | 29.9
| CHD | 19.3 | 45.9 | 34.9
| GIH | 27.7 | 45.5 | 26.7
| LWK | 21.8 | 51.8 | 26.4
| MEX | 10.3 | 46.6 | 43.1
| MKK | 21.2 | 55.8 | 23.1
| TSI | 10.8 | 48.0 | 41.2
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=19060911
|Trait=Cholesterol, total
|Title=Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
|RiskAllele=G
|Pval=4E-7
|OR=0.05
|ORtxt=[NR] SD decrease
|OA=1
}}
{{PMID Auto GWAS
|PMID=19060910
|Trait=HDL cholesterol
|Title=Genome-wide association analysis of metabolic traits in a birth cohort from a founder population
|RiskAllele=A
|Pval=2E-10
|OR=0.05
|ORtxt=[0.03-0.06] mmol/l increase
|OA=1
}}

{{PharmGKB
|RSID=rs1532085
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19802338
|Annotation=Phenotype: In a GWAS, this SNP was significantly associated with plasma concentrations of HDL-C and apolipoprotein A1. Study size: 6382. Study population/ethnicity: Caucasian women. Significance metric(s): HDL-C: p = 1.3 x 10 (-10);ApoA1: p = 9.0 x 10(-14). Type of association: CO; GN
|Drugs=
|Drug Classes=
|Diseases=Cardiovascular Diseases
|Curation Level=Curated
|PharmGKB Accession ID=PA165111814
}}

{{PharmGKB
|RSID=rs1532085
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19060911; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. (Initial Sample Size: 22,562 individuals; Replication Sample Size: NR); (Region: 15q22.1; Reported Gene(s): LIPC; Risk Allele: rs1532085-G); (p-value= 0.0000004).This variant is associated with Cholesterol, total.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740190
}}

{{PharmGKB
|RSID=rs1532085
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19060910; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. (Initial Sample Size: 4,763 individuals; Replication Sample Size: NR); (Region: 15q22.1; Reported Gene(s): LIPC; Risk Allele: rs1532085-A); (p-value= 0.0000000002).This variant is associated with HDL cholesterol.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740270
}}

{{PharmGKB
|RSID=rs1532085
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19060911; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. (Initial Sample Size: 21,412 individuals; Replication Sample Size: NR); (Region: 15q22.1; Reported Gene(s): LIPC; Risk Allele: rs1532085-G); (p-value= 1E-35).This variant is associated with HDL cholesterol.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740207
}}

{{omim
|id=612797
|rsnum=1532085
}}

{{PMID Auto
|PMID=21867541
|Title=Evaluation of the global association between cholesterol-associated polymorphisms and Alzheimer's disease suggests a role for rs3846662 and HMGCR splicing in disease risk
|OA=1
}}

{{PMID Auto GWAS
|PMID=20686565
|Trait=None
|Title=Biological, clinical and population relevance of 95 loci for blood lipids.
|RiskAllele=A
|Pval=0
|OR=1.4500
|ORtxt=None
|OA=1
}}

{{PMID Auto GWAS
|PMID=22399527
|Trait=None
|Title=Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
|RiskAllele=G
|Pval=5E-24
|OR=0.1300
|ORtxt=None
|OA=1
}}

{{PMID Auto
|PMID=19041386
|Title=Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.
|OA=1
}}

{{PMID Auto
|PMID=19936222
|Title=Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.
|OA=1
}}

{{PMID Auto
|PMID=19951432
|Title=Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.
|OA=1
}}

{{PMID Auto
|PMID=20502693
|Title=Genetics and beyond--the transcriptome of human monocytes and disease susceptibility.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1532085
|overall_frequency_n=72
|overall_frequency_d=128
|overall_frequency=0.5625
|n_genomes=42
|n_genomes_annotated=0
|n_haplomes=59
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=23222517
  |Trait=Red blood cell traits
  |Title=Seventy-five genetic loci influencing the human red blood cell.
  |RiskAllele=G
  |Pval=7E-11
  |OR=.03
  |ORtxt=[0.022-0.046] unit increase
  |OA=1
}}

{{PMID Auto GWAS
  |PMID=22916037
  |Trait=Metabolite levels
  |Title=Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
  |RiskAllele=
  |Pval=9E-104
  |OR=NR
  |ORtxt=NR
  |OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}