{{Rsnum
|rsid=1532268
|Gene=MTRR
|Chromosome=5
|position=7878066
|Orientation=minus
|GMAF=0.2539
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=MTRR
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 8.0 | 45.5 | 46.4
| HCB | 1.5 | 23.4 | 75.2
| JPT | 0.9 | 8.8 | 90.3
| YRI | 3.4 | 37.9 | 58.6
| ASW | 8.9 | 48.2 | 42.9
| CHB | 1.5 | 23.4 | 75.2
| CHD | 2.8 | 25.0 | 72.2
| GIH | 14.9 | 43.6 | 41.6
| LWK | 12.7 | 41.8 | 45.5
| MEX | 1.8 | 28.1 | 70.2
| MKK | 21.8 | 53.8 | 24.4
| TSI | 11.8 | 50.0 | 38.2
| HapMapRevision=28
}}{{PMID Auto
|PMID=21211571
|Title=MTHFR and MTRR genotype and haplotype analysis and colorectal cancer susceptibility in a case-control study from the Czech Republic
}}

{{PMID Auto
|PMID=19064578
|Title=No association of single nucleotide polymorphisms in one-carbon metabolism genes with prostate cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=19112534
|Title=Lack of association of polymorphisms in homocysteine metabolism genes with pseudoexfoliation syndrome and glaucoma.
|OA=1
}}

{{PMID Auto
|PMID=19493349
|Title=118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects.
|OA=1
}}

{{PMID Auto
|PMID=19657388
|Title=Lack of association between genetic polymorphisms in enzymes associated with folate metabolism and unexplained reduced sperm counts.
|OA=1
}}

{{PMID Auto
|PMID=23358257
|Title=Analysis of MTHFR and MTRR Gene Polymorphisms in Iranian Ventricular Septal Defect Subjects
|OA=1
}}

{{GET Evidence
|gene=MTRR
|aa_change=Ser202Leu
|aa_change_short=S202L
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1532268
|overall_frequency_n=3533
|overall_frequency_d=10758
|overall_frequency=0.328407
|n_genomes=24
|n_genomes_annotated=0
|n_haplomes=26
|n_articles=0
|n_articles_annotated=0
|qualityscore_in_silico=1
|qualitycomment_in_silico=Y
|gene_in_genetests=Y
|genetests_testable=Y
|genetests_reviewed=Y
|nblosum100=6
|autoscore=3
|n_web_uneval=2
}}

{{PMID Auto
|PMID=22706675
|Title=Folic acid supplementation, MTHFR and MTRR polymorphisms, and the risk of childhood leukemia: the ESCALE study (SFCE).
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}