{{Rsnum
|rsid=1540771
|Chromosome=6
|position=466033
|Orientation=plus
|GMAF=0.3489
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 26.1 | 58.6 | 15.3
| HCB | 5.1 | 39.4 | 55.5
| JPT | 11.5 | 43.4 | 45.1
| YRI | 0.0 | 12.2 | 87.8
| ASW | 5.3 | 33.3 | 61.4
| CHB | 5.1 | 39.4 | 55.5
| CHD | 8.3 | 42.2 | 49.5
| GIH | 12.9 | 36.6 | 50.5
| LWK | 0.9 | 18.3 | 80.7
| MEX | 22.4 | 50.0 | 27.6
| MKK | 3.2 | 27.6 | 69.2
| TSI | 23.5 | 52.9 | 23.5
| HapMapRevision=28
}}[http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1000074 plos] the association between [[rs12203592]] and [[hair color]] was independent of [[rs1540771]], a SNP between the IRF4 and EXOC2 genes previously found to be associated with hair color.

{{GWAS Summary
|SNP=rs1540771
|PubMedID=17952075
|Condition=Freckles
|Gene=SEC5L1,IRF4
|Risk Allele=A
|pValue=4.00E-018
|OR=1.4
|95CI=1.26-1.57
}}

{{omim
|desc=SKIN/HAIR/EYE PIGMENTATION, VARIATION IN, 8; SHEP8
|id=611724
|rsnum=1540771
}}

{{PharmGKB
|RSID=rs1540771
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17952075; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genetic determinants of hair, eye and skin pigmentation in Europeans (Initial Sample Size: 2,986 individuals; Replication Sample Size: 3,932 individuals). This variant is associated with freckles.
|Drugs=
|Drug Classes=
|Diseases=Melanosis
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356693
}}

{{PMID Auto
|PMID=18483556
|Title=A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation.
|OA=1
}}

{{PMID Auto
|PMID=19340012
|Title=Genome-wide association study of tanning phenotype in a population of European ancestry.
|OA=1
}}

{{PMID Auto
|PMID=19474294
|Title=Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.
|OA=1
}}

{{PMID Auto
|PMID=19884608
|Title=Interactive effect of stressful life events and the serotonin transporter 5-HTTLPR genotype on posttraumatic stress disorder diagnosis in 2 independent populations.
|OA=1
}}

{{PMID Auto
|PMID=20585627
|Title=Web-based, participant-driven studies yield novel genetic associations for common traits.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1540771
|overall_frequency_n=43
|overall_frequency_d=128
|overall_frequency=0.335938
|n_genomes=29
|n_genomes_annotated=0
|n_haplomes=37
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Affy500k}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}