{{Rsnum
|rsid=1541160
|Gene=KIFAP3
|Chromosome=1
|position=170026661
|Orientation=minus
|GMAF=0.1534
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=KIFAP3
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 51.3 | 35.4 | 13.3
| HCB | 97.8 | 2.2 | 0.0
| JPT | 100.0 | 0.0 | 0.0
| YRI | 70.5 | 26.7 | 2.7
| ASW | 57.9 | 40.4 | 1.8
| CHB | 97.8 | 2.2 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 74.3 | 24.8 | 1.0
| LWK | 80.9 | 18.2 | 0.9
| MEX | 72.4 | 25.9 | 1.7
| MKK | 83.3 | 16.7 | 0.0
| TSI | 55.4 | 38.6 | 5.9
| HapMapRevision=28
}}{{PMID|19451621|OA=1
}} homozygosity for the favorable allele (CC) associated with a 14 month survival advantage in [[ALS]] patients. further analysis (sequence, genotypic, and functional) showed LD between [[rs1541160]] and [[rs522444]] and that favorable alleles correlate with reduced [[KIFAP3]] expression.

However, a later study attempting to replicate these findings in a population-based cohort of 500 Italian ALS patients could not find any effect on either survival or gene expression based on any SNPs (including [[rs1541160]]) from the KIFAP3 locus.{{PMID|20566859|OA=1
}}

{{omim
|id=105400
|rsnum=1541160
}}

{{PMID Auto
|PMID=21659726
|Title=Genetic Variation in KIFAP3 Is Associated with an Upper Motor Neuron-Predominant Phenotype in Amyotrophic Lateral Sclerosis
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1541160
|overall_frequency_n=106
|overall_frequency_d=128
|overall_frequency=0.828125
|n_genomes=55
|n_genomes_annotated=0
|n_haplomes=94
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=22795786
|Title=No association of five candidate genetic variants with amyotrophic lateral sclerosis in a Chinese population
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}