{{Rsnum
|rsid=1544105
|Chromosome=9
|position=127800446
|Orientation=minus
|GMAF=0.4885
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 12.4 | 46.9 | 40.7
| HCB | 44.5 | 42.3 | 13.1
| JPT | 47.8 | 41.6 | 10.6
| YRI | 34.7 | 44.9 | 20.4
| ASW | 40.4 | 43.9 | 15.8
| CHB | 44.5 | 42.3 | 13.1
| CHD | 49.5 | 40.4 | 10.1
| GIH | 13.9 | 55.4 | 30.7
| LWK | 31.8 | 49.1 | 19.1
| MEX | 27.6 | 44.8 | 27.6
| MKK | 44.9 | 44.9 | 10.3
| TSI | 13.7 | 51.0 | 35.3
| HapMapRevision=28
}}{{PMID Auto
|PMID=19902562
|Title=Purine biosynthetic pathway genes and methotrexate response in rheumatoid arthritis patients among north Indians
}}

{{PharmGKB
|RSID=rs1544105
|Name_s=
|Gene_s=FPGS
|Feature=
|Evidence=PubMed ID:19902562
|Annotation=Risk or phenotype-associated allele (s): A/A and A/G. Phenotype: Carriers of the FPGS rs1544105 AA and AG genotypes [OR (95% CI) = 3.47 (1.19-10.12)] were predictors of poor response to methotrexate among rheumatoid arthritis patients Study size: 281. Study population/ethnicity: Indian metric(s): OR (95% CI) = 3.47 (1.19-10.12). Type of association: GN.
|Drugs=methotrexate
|Drug Classes=
|Diseases=Arthritis, Rheumatoid
|Curation Level=Curated
|PharmGKB Accession ID=PA165110199
}}

{{PMID Auto
|PMID=18632090
|Title=Genome-wide linkage analyses of quantitative and categorical autism subphenotypes.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1544105
|overall_frequency_n=66
|overall_frequency_d=128
|overall_frequency=0.515625
|n_genomes=40
|n_genomes_annotated=0
|n_haplomes=54
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=24908438
|Title=Influence of genetic polymorphisms of FPGS, GGH, and MTHFR on serum methotrexate levels in Chinese children with acute lymphoblastic leukemia
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}