{{Rsnum
|rsid=1554973
|Gene=TLR4
|Chromosome=9
|position=117718534
|Orientation=plus
|GMAF=0.326
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 4.4 | 34.5 | 61.1
| HCB | 0.0 | 27.7 | 72.3
| JPT | 1.8 | 21.2 | 77.0
| YRI | 71.4 | 26.5 | 2.0
| ASW | 35.1 | 50.9 | 14.0
| CHB | 0.0 | 27.7 | 72.3
| CHD | 3.7 | 19.3 | 77.1
| GIH | 10.9 | 32.7 | 56.4
| LWK | 53.6 | 40.0 | 6.4
| MEX | 1.7 | 29.3 | 69.0
| MKK | 51.9 | 39.7 | 8.3
| TSI | 3.9 | 35.3 | 60.8
| HapMapRevision=28
}}[[rs1554973]] is a SNP near the toll-like receptor 4 [[TLR4]] gene.

A study of 109 pregnant women focusing on [[TLR4]] SNPs associated with [[chorionic plate inflammation]] concluded that [[rs1554973]] was associated with increased risk when present in the fetal genome. The risk allele's increased odds ratio for clinically significant inflammation was 4.95 (CI: 3.0-5.6, p = .005). {{PMID|18928988}}

{{PMID Auto
|PMID=19554026
|Title=Genetic association of Toll-like receptor 4 with cervical cytokine concentrations during pregnancy
|OA=1
}}

{{PMID|19134200|OA=1
}} No evidence of major effects in several Toll-like receptor gene polymorphisms in rheumatoid arthritis.

{{PMID|20049212|OA=1
}} Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS).

{{PMID|20200442|OA=1
}} Sequence variants in the TLR4 and TLR6-1-10 genes and prostate cancer risk. Results based on pooled analysis from three independent studies.

{{PMID|20463618|OA=1
}} Role of polymorphic variants as genetic modulators of infection in neonatal sepsis.

{{PMID|21704385|OA=1
}} Interaction between interleukin-1 receptor 2 and Toll-like receptor 4, and cervical cytokines.

{{PMID Auto
|PMID=23161283
|Title=SNPs in toll-like receptor (TLR) genes as new genetic alterations associated with congenital toxoplasmosis?
|OA=1
}}

{{PMID Auto
|PMID=24971461
|Title=Polymorphisms in the Inflammatory Pathway Genes TLR2, TLR4, TLR9, LY96, NFKBIA, NFKB1, TNFA, TNFRSF1A, IL6R, IL10, IL23R, PTPN22, and PPARG Are Associated with Susceptibility of Inflammatory Bowel Disease in a Danish Cohort
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}