{{Rsnum
|rsid=1556314
|Gene=TRPM2
|Chromosome=21
|position=44391460
|Orientation=plus
|ReferenceAllele=T
|MissenseAllele=G
|GMAF=0.2117
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=TRPM2
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 1.8 | 31.2 | 67.0
| HCB | 0.7 | 23.0 | 76.3
| JPT | 6.2 | 36.3 | 57.5
| YRI | 11.6 | 42.2 | 46.3
| ASW | 7.0 | 33.3 | 59.6
| CHB | 0.7 | 23.0 | 76.3
| CHD | 1.8 | 26.6 | 71.6
| GIH | 3.0 | 23.0 | 74.0
| LWK | 10.0 | 48.2 | 41.8
| MEX | 5.3 | 22.8 | 71.9
| MKK | 12.9 | 47.1 | 40.0
| TSI | 3.0 | 20.8 | 76.2
| HapMapRevision=28
}}
{{PMID|19133961}} [[rs1556314]] associated with [[bipolar disorder]] type I
*C-T-A haplotype of SNPs [[rs1618355]](C), [[rs933151]](T), and [[rs749909]](A) was significantly associated with early age at onset in BD-I families

{{omim
|desc=MAJOR AFFECTIVE DISORDER 1; MAFD1
|id=125480
|rsnum=1556314
}}

{{omim
|desc=TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 2;
|id=603749
|rsnum=1556314
}}

{{PMID Auto
|PMID=16205735
|Title=Fine mapping of a susceptibility locus for bipolar and genetically related unipolar affective disorders, to a region containing the C21ORF29 and TRPM2 genes on chromosome 21q22.3.
}}

{{GET Evidence
|gene=TRPM2
|aa_change=Asp543Glu
|aa_change_short=D543E
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1556314
|overall_frequency_n=2491
|overall_frequency_d=10758
|overall_frequency=0.231549
|n_genomes=18
|n_genomes_annotated=0
|n_haplomes=22
|n_articles=0
|n_articles_annotated=0
|nblosum100=-2
|autoscore=0
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}