{{Rsnum
|rsid=1558902
|Gene=FTO
|Chromosome=16
|position=53769662
|Orientation=plus
|GMAF=0.2479
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;T)
|geno3=(T;T)
|Gene_s=FTO
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;T)
| geno3=(T;T)
| CEU | 15.4 | 63.1 | 21.5
| HCB | 0.0 | 24.4 | 75.6
| JPT | 6.8 | 18.2 | 75.0
| YRI | 0.0 | 11.3 | 88.7
| ASW | 0.0 | 0.0 | 0.0
| CHB | 0.0 | 24.4 | 75.6
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=19557197
|Trait=Waist circumference
|Title=NRXN3 Is a Novel Locus for Waist Circumference: A Genome-Wide Association Study from the CHARGE Consortium
|RiskAllele=
|Pval=5E-19
|OR=NR
|ORtxt=NR
|OA=1
}}

{{PMID Auto
|PMID=20075932
|Title=Association of gene polymorphism of the fat-mass and obesity-associated gene with insulin resistance in Japanese
}}
{{PMID Auto GWAS
|PMID=20421936
|Trait=Obesity (extreme)
|Title=Two new loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and German study groups
|RiskAllele=A
|Pval=7E-13
|OR=1.37
|ORtxt=[1.26-1.50]
|OA=1
}}
{{PMID Auto GWAS
|PMID=20935630
|Trait=None
|Title=Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
|RiskAllele=A
|Pval=5E-120
|OR=0.39
|ORtxt=[0.35-0.43] kg/m2 increase
|OA=1
}}

{{PMID Auto
|PMID=21443588
|Title=Association between the FTO gene and overweight in Japanese children and adolescents
}}

{{PMID Auto GWAS
|PMID=21544081
|Trait=None
|Title=Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations.
|RiskAllele=T
|Pval=1E-7
|OR=0.0900
|ORtxt=[0.06-0.12] unit decrease
}}

{{PMID Auto
|PMID=21796137
|Title=Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population
}}

{{PMID Auto
|PMID=22235250
|Title=Quantile-specific penetrance of genes affecting lipoproteins, adiposity and height
|OA=1
}}

{{PMID Auto
|PMID=22589738
|Title=Genome-Wide Association for Abdominal Subcutaneous and Visceral Adipose Reveals a Novel Locus for Visceral Fat in Women
|OA=1
}}
{{PMID Auto
|PMID=18379722
|Title=Variations in the FTO gene are associated with severe obesity in the Japanese.
|OA=1
}}

{{PMID Auto
|PMID=20703240
|Title=Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population.
}}

{{PMID Auto
|PMID=22041983
|Title=Recapitulation of genome-wide association studies on body mass index in the Korean population.
}}

{{PMID Auto
|PMID=22222230
|Title=FTO gene polymorphisms and platelet counts in a general Japanese population.
}}

{{PMID Auto
|PMID=22504289
|Title=<i>FTO</i>, Abdominal Adiposity, Fasting Hyperglycemia Associated with Elevated HbA1c in Japanese Middle-Aged Women.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1558902
|overall_frequency_n=36
|overall_frequency_d=126
|overall_frequency=0.285714
|n_genomes=21
|n_genomes_annotated=0
|n_haplomes=26
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23254338
|Title=FTO First Intron rs1558902 Variant and Platelets Count in White Middle-aged Women:  Prague Pre and Post Menopausal Females (3PMFs) Study
}}

{{PMID Auto
|PMID=24084939
|Title=A common biological basis of obesity and nicotine addiction
|OA=1
}}

{{PMID Auto
|PMID=24106974
|Title=Association between fat mass and obesity-associated (FTO) gene and hip fracture susceptibility
}}

{{PMID Auto GWAS
  |PMID=23563607
  |Trait=Obesity
  |Title=Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
  |RiskAllele=A
  |Pval=2E-81
  |OR=1.14
  |ORtxt=[NR]
  |OA=1
}}

{{PMID Auto
|PMID=22891219
|Title=FTO genotype and 2-year change in body composition and fat distribution in response to weight-loss diets: the POUNDS LOST Trial.
|OA=1
}}

{{PMID Auto
|PMID=23471855
|Title=The genetics of childhood obesity and interaction with dietary macronutrients.
|OA=1
}}

{{PMID Auto
|PMID=24911064
|Title=Association of FTO Polymorphisms with Obesity and Metabolic Parameters in Han Chinese Adolescents
}}

{{PMID Auto
|PMID=24983943
|Title=Effects of BMI, Fat Mass, and Lean Mass on Asthma in Childhood: A Mendelian Randomization Study
}}

{{PMID Auto
|PMID=25091360
|Title=Fat-mass and obesity-associated gene variant and changes of body mass index from ages 3 to 13 years
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}