{{Rsnum
|rsid=1571801
|Gene=DAB2IP
|Chromosome=9
|position=121665094
|Orientation=plus
|GMAF=0.1667
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=DAB2IP
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 7.1 | 43.8 | 49.1
| HCB | 0.0 | 13.3 | 86.7
| JPT | 0.0 | 6.8 | 93.2
| YRI | 1.4 | 26.0 | 72.6
| ASW | 3.6 | 32.1 | 64.3
| CHB | 0.0 | 13.3 | 86.7
| CHD | 0.0 | 9.4 | 90.6
| GIH | 3.0 | 18.8 | 78.2
| LWK | 0.0 | 23.8 | 76.2
| MEX | 1.8 | 28.1 | 70.2
| MKK | 1.9 | 29.2 | 68.8
| TSI | 3.0 | 27.3 | 69.7
| HapMapRevision=28
}}In a study of ~1000 Caucasian patients with prostate cancer, [[rs1571801]] was the SNP most associated with not only [[prostate cancer]], but having an aggressive form of it. The odds ratio for aggressive prostate cancer associated with the risk allele, [[rs1571801(A)]], was 1.36 (CI: 1.13 - 1.65, p = 0.001). The odds ratio associated with (nonaggressive) prostate cancer was also higher than average for this SNP; for the same (A) risk allele, it was 1.27 (CI: 1.10 - 1.48, p = 0.0017). {{PMID|18073375}}

Although the association was found in a study of Caucasian patients, it was also reported to be statistically significant in a population of 210 African-Americans with prostate cancer. {{PMID|18073375}}

According to [http://www.oncology-information.com/CancerLineHCP/6096_31566_2__.aspx], "The odds ratio for aggressive prostate cancer ranged from 1.29 to 1.50 in men with one or two copies of the mutant A allele compared with noncarriers."

[[rs1571801]] is located in the DAB2IP gene and encodes a novel Ras GTPase-activating protein and putative prostate tumor suppressor.

{{PMID|18073375}} Associated with aggressive prostate cancer in a study of [[prostate cancer]] patients of European descent.  Also statistically significant in an African American study population.  

{{PMID Auto
|PMID=22046421
|Title=A Common Genetic Variant (97906C&gt;A) of DAB2IP/AIP1 Is Associated with an Increased Risk and Early Onset of Lung Cancer in Chinese Males
|OA=1
}}

{{PMID Auto
|PMID=18794092
|Title=Association of prostate cancer risk variants with clinicopathologic characteristics of the disease.
|OA=1
}}

{{PMID Auto
|PMID=19434657
|Title=Individual and cumulative effect of prostate cancer risk-associated variants on clinicopathologic variables in 5,895 prostate cancer patients.
|OA=1
}}

{{PMID Auto
|PMID=19549807
|Title=Prostate cancer risk associated loci in African Americans.
|OA=1
}}

{{PMID Auto
|PMID=20039378
|Title=Estimation of genotype relative risks from pedigree data by retrospective likelihoods.
|OA=1
}}

{{PMID Auto
|PMID=21390317
|Title=Characterizing associations and SNP-environment interactions for GWAS-identified prostate cancer risk markers--results from BPC3.
|OA=1
}}

{{PMID Auto
|PMID=21538423
|Title=Early onset prostate cancer has a significant genetic component.
|OA=1
}}

{{PMID Auto
|PMID=22077888
|Title=Association of prostate cancer risk alleles with unfavourable pathological characteristics in potential candidates for active surveillance.
}}

{{PMID Auto
|PMID=23159463
|Title=Genetic sequence variants are associated with severity of lower urinary tract symptoms and prostate cancer susceptibility.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | Illumina Human 1M}}