{{Rsnum
|rsid=1573496
|Gene=ADH7
|Chromosome=4
|position=99428512
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=C
|GMAF=0.05785
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=ADH7
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 80.0 | 20.0 | 0.0
| HCB | 100.0 | 0.0 | 0.0
| JPT | 100.0 | 0.0 | 0.0
| YRI | 100.0 | 0.0 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 100.0 | 0.0 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[[rs1573496]] is a SNP in the [[ADH7]] alcohol dehydrogenase 7 gene.

A study of over 3,800 cases of "upper aerodigestive" [[cancers]] (mouth/throat, voice box, and esophageal cancers) concluded that the [[rs1573496]](G) allele has a protective effect. Carriers of this allele had a 0.68x (decreased; p=10<sup>-9</sup>) risk of having one of these cancer types.{{PMID|18500343}}

{{PMID Auto
|PMID=19861527
|Title=Impact of multiple alcohol dehydrogenase gene polymorphisms on risk of upper aerodigestive tract cancers in a Japanese population
}}

{{PMID Auto
|PMID=20336794
|Title=A single nucleotide polymorphism in the alcohol dehydrogenase 7 gene (alanine to glycine substitution at amino acid 92) is associated with the risk of squamous cell carcinoma of the head and neck
|OA=1
}}

{{omim
|id=103720
|rsnum=1573496
}}

{{PMID|21437268|OA=1
}} A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium. The data in this paper, makes it seem that (G;G) was much more common. This is inconsistent with the HapMap frequencies, suggesting the sequence may have been flipped.

{{PMID|16685648|OA=1
}} Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence.

{{PMID|17185388|OA=1
}} Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans.

{{PMID|17273965|OA=1
}} Evidence of positive selection on a class I ADH locus.

{{PMID|18331377|OA=1
}} Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample.

{{PMID|19193628|OA=1
}} ADH single nucleotide polymorphism associations with alcohol metabolism in vivo.

{{PMID|19298322|OA=1
}} Associations and interactions between SNPs in the alcohol metabolizing genes and alcoholism phenotypes in European Americans.

{{PMID|19687126|OA=1
}} A non-synonymous variant in ADH1B is strongly associated with prenatal alcohol use in a European sample of pregnant women.

{{PMID|20700531|OA=1
}} The association of alcohol and alcohol metabolizing gene variants with diabetes and coronary heart disease risk factors in a white population.

{{GET Evidence
|gene=ADH7
|aa_change=Gly92Ala
|aa_change_short=G92A
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1573496
|overall_frequency_n=856
|overall_frequency_d=10758
|overall_frequency=0.0795687
|n_genomes=8
|n_genomes_annotated=0
|n_haplomes=10
|n_articles=0
|n_articles_annotated=0
|nblosum100=1
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=23149980
|Title=Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphisms, alcohol intake and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study
}}

[[Esophageal Cancer: Preliminary Research]]

[[Larynx Cancer]]

[[Oral and Throat Cancers]]

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}