{{Rsnum
|rsid=1588265
|Gene=PDE4D
|Chromosome=5
|position=60073967
|Orientation=plus
|GMAF=0.3774
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=PDE4D
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 38.9 | 50.4 | 10.6
| HCB | 5.8 | 47.4 | 46.7
| JPT | 6.2 | 41.6 | 52.2
| YRI | 70.7 | 27.2 | 2.0
| ASW | 59.6 | 36.8 | 3.5
| CHB | 5.8 | 47.4 | 46.7
| CHD | 7.3 | 24.8 | 67.9
| GIH | 51.5 | 34.7 | 13.9
| LWK | 58.2 | 38.2 | 3.6
| MEX | 61.4 | 33.3 | 5.3
| MKK | 69.2 | 26.3 | 4.5
| TSI | 55.9 | 40.2 | 3.9
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=19426955
|Trait=Asthma
|Title=Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene
|RiskAllele=G
|Pval=3E-8
|OR=0.85
|ORtxt=[0.77-0.93]
|OA=1
}}

{{PharmGKB
|RSID=rs1588265
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19426955
|Annotation=In a Genome Wide Association Study of White and Hispanic populations, the minor allele G of rs1588265 was significantly associated with protection from asthma. This association did not replicate in black populations studied; these populations have very different linkage disequilibrium patterns from the White and Hispanic populations, implying that this variant may be associated but not causal of the phenotype.
|Drugs=
|Drug Classes=
|Diseases=Asthma
|Curation Level=Curated
|PharmGKB Accession ID=PA164856892
}}

{{PMID Auto
|PMID=20698975
|Title=Asthma-susceptibility variants identified using probands in case-control and family-based analyses.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1588265
|overall_frequency_n=44
|overall_frequency_d=128
|overall_frequency=0.34375
|n_genomes=28
|n_genomes_annotated=0
|n_haplomes=35
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23028483
|Title=Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}