{{Rsnum
|rsid=16022
|Gene=CACNA1A
|Chromosome=19
|position=13298882
|Orientation=minus
|GMAF=0.1129
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=CACNA1A
}}[[rs16022]], also known as E918D, is a SNP in the  calcium channel, voltage-dependent, P/Q type, alpha 1A subunit [[CACNA1A]] gene.

On it's own it is not associated with [[migraines]]; however, individuals with both this SNP and a variant [[rs16023]] have a 2x increased risk of any type of [[migraine]], at least if a study of ~100 Italian patients is correct.{{PMID|19429006}}

{{ClinVar
|rsid=16022
|Reversed=1
|FwdREF=G
|FwdALT=C
|REF=C
|ALT=G
|RSPOS=13409696
|CHROM=19
|GMAF=0.1131
|dbSNPBuildID=54
|SSR=0
|SAO=0
|VP=0x050168000000170016100100
|GENEINFO=CACNA1A:773
|GENE_NAME=CACNA1A
|GENE_ID=773
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000019.9:g.13409696C>G
|CLNSIG=1
|Tags=RV;PM;PMC;SLO;VLD;G5A;G5;KGPhase1;KGPROD;OTHERKG;LSD
|CAF=0.8871; 0.1129
|COMMON=1
|CLNACC=RCV000059296.1
|CLNDBN=not provided
|CLNSRC=UniProtKB (variants)
|CLNSRCID=VAR_014459
|Disease=not provided
}}

{{PMID Auto
|PMID=16866717
|Title=Migrainous vertigo: mutation analysis of the candidate genes CACNA1A, ATP1A2, SCN1A, and CACNB4.
}}

{{GET Evidence
|gene=CACNA1A
|aa_change=Glu920Asp
|aa_change_short=E920D
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs16022
|overall_frequency_n=1
|overall_frequency_d=44
|overall_frequency=0.0227273
|n_genomes=1
|n_genomes_annotated=0
|n_haplomes=1
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|genetests_testable=Y
|genetests_reviewed=Y
|nblosum100=-2
|autoscore=3
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}