{{Rsnum
|rsid=16023
|Gene=CACNA1A
|Chromosome=19
|position=13298658
|Orientation=minus
|GMAF=0.1244
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;T)
|geno3=(T;T)
|Gene_s=CACNA1A
}}[[rs16023]], also known as E993V, is a SNP in the  calcium channel, voltage-dependent, P/Q type, alpha 1A subunit [[CACNA1A]] gene.

On it's own it is not associated with [[migraines]]; however, individuals with both this SNP and a variant [[rs16022]] have a 2x increased risk of any type of [[migraine]], at least if a study of ~100 Italian patients is correct.{{PMID|19429006}}

{{ClinVar
|rsid=16023
|Reversed=1
|FwdREF=A
|FwdALT=T
|REF=T
|ALT=A
|RSPOS=13409472
|CHROM=19
|GMAF=0.1245
|dbSNPBuildID=54
|SSR=0
|SAO=0
|VP=0x050168000000170116100100
|GENEINFO=CACNA1A:773
|GENE_NAME=CACNA1A
|GENE_ID=773
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000019.9:g.13409472T>A
|CLNSIG=1
|Tags=RV;PM;PMC;SLO;VLD;G5A;G5;GNO;KGPhase1;KGPROD;OTHERKG;LSD
|CAF=0.8756; 0.1244
|COMMON=1
|CLNACC=RCV000059297.1
|CLNDBN=not provided
|CLNSRC=UniProtKB (variants)
|CLNSRCID=VAR_043828
|Disease=not provided
}}

{{PMID Auto
|PMID=16866717
|Title=Migrainous vertigo: mutation analysis of the candidate genes CACNA1A, ATP1A2, SCN1A, and CACNB4.
}}

{{GET Evidence
|gene=CACNA1A
|aa_change=Glu995Val
|aa_change_short=E995V
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs16023
|overall_frequency_n=4
|overall_frequency_d=80
|overall_frequency=0.05
|n_genomes=3
|n_genomes_annotated=0
|n_haplomes=3
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|pph2_score=0.125
|genetests_testable=Y
|genetests_reviewed=Y
|nblosum100=5
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}