{{Rsnum
|rsid=1611115
|Gene=DBH
|Chromosome=9
|position=133635393
|Orientation=plus
|GMAF=0.2075
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=DBH
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 65.2 | 31.2 | 3.6
| HCB | 66.9 | 28.7 | 4.4
| JPT | 66.1 | 33.0 | 0.9
| YRI | 70.5 | 25.3 | 4.1
| ASW | 59.6 | 36.8 | 3.5
| CHB | 66.9 | 28.7 | 4.4
| CHD | 67.0 | 31.2 | 1.8
| GIH | 58.4 | 34.7 | 6.9
| LWK | 76.9 | 20.4 | 2.8
| MEX | 38.6 | 50.9 | 10.5
| MKK | 63.5 | 32.1 | 4.5
| TSI | 57.8 | 37.3 | 4.9
| HapMapRevision=28
}}
[[rs1611115]] (C-1021T) is a SNP near the [[dopamine]] beta-hydroxylase ([[DBH]]) gene.

per OMIM, the T allele is associated with lower DBH expression in plasma (16 of TT genotype had DBH activity of 4.1, 46 of CT genotype had DBH activity of 25.2, and 112 of CC genotype had DBH activity of 48.1 nmol/min/ml)

Association tests related to [[affective disorders]] such as [[ADHD]] were performed using four independent samples, healthy volunteers (N = 387), patients with affective disorders (N = 182), adult attention deficit hyperactivity disorder (ADHD) patients (N = 407), and patients with personality disorders (N = 637). Personality disorder patients carrying the DBH TT genotype exhibited higher neuroticism and novelty seeking scores as compared to individuals with the (C;C) or (C;T) genotype. Analyses on the level of the neuroticism and novelty seeking subscales revealed that the DBH (T;T) genotype was primarily associated with personality features related to impulsiveness and aggressive hostility. Also adult ADHD patients carrying the homozygous (T;T) genotypes displayed by significantly increased neuroticism scores; when both personality disorder and adult ADHD patient were analyzed together, (T;T) carriers also displayed by significantly lower conscientiousness levels. {{PMID|18982239}}

This study concludes that [[rs1611115]](T;T) homozygotes appear to be at increased risk for [[personality traits]] related to impulsiveness, aggression, and adult ADHD. {{PMID|18982239}}

Dopamine-beta-hydroxylase in postural tachycardia syndrome. T allele associated with lower plasma [[DBH]] levels, and accounts for up to 52% of variation in plasma [[DBH]], but not linked to increased susceptibility to [[postural tachycardia syndrome]] (POTS). {{PMID|17625104}}

{{PMID Auto
|PMID=20498626
|Title=Role of polymorphisms in dopamine synthesis and metabolism genes and association of DBH haplotypes with Parkinson's disease among North Indians
}}
{{PMID Auto
|PMID=19757024
|Title=Study on DBH genetic polymorphisms and plasma activity in attention deficit hyperactivity disorder patients from Eastern India
}}
{{PMID Auto
|PMID=21070631
|Title=The dopamine beta-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project
|OA=1
}}

{{PMID Auto
|PMID=22761865
|Title=Dopamine Beta Hydroxylase Genotype Identifies Individuals Less Susceptible to Bias in Computer-Assisted Decision Making
|OA=1
}}

{{PMID Auto
|PMID=16616730
|Title=A single nucleotide polymorphism at DBH, possibly associated with attention-deficit/hyperactivity disorder, associates with lower plasma dopamine beta-hydroxylase activity and is in linkage disequilibrium with two putative functional single nucleotide polymorphisms.
}}

{{PMID Auto
|PMID=17457369
|Title=Genotypic and haplotypic associations of the DBH gene with plasma dopamine beta-hydroxylase activity in African Americans.
}}

{{PMID Auto
|PMID=18172755
|Title=Correlation of plasma dopamine beta-hydroxylase activity with polymorphisms in DBH gene: a study on Eastern Indian population.
}}

{{PMID Auto
|PMID=18180394
|Title=Genetic variation within adrenergic pathways determines in vivo effects of presynaptic stimulation in humans.
|OA=1
}}

{{PMID Auto
|PMID=18330705
|Title=Physiogenomic analysis of localized FMRI brain activity in schizophrenia.
|OA=1
}}

{{PMID Auto
|PMID=18466599
|Title=Linkage studies of catechol-O-methyltransferase (COMT) and dopamine-beta-hydroxylase (DBH) cDNA expression levels.
|OA=1
}}

{{PMID Auto
|PMID=18722802
|Title=Dopamine beta-hydroxylase -1021C>T association and Parkinson's disease.
|OA=1
}}

{{PMID Auto
|PMID=19604093
|Title=Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients.
|OA=1
}}

{{PMID Auto
|PMID=19673036
|Title=Association of tagging single nucleotide polymorphisms on 8 candidate genes in dopaminergic pathway with schizophrenia in Croatian population.
|OA=1
}}

{{PMID Auto
|PMID=20621148
|Title=Genotype-controlled analysis of serum dopamine beta-hydroxylase activity in civilian post-traumatic stress disorder.
|OA=1
}}

{{PMID Auto
|PMID=21216270
|Title=Role of gene-gene/gene-environment interaction in the etiology of eastern Indian ADHD probands.
}}

{{PMID Auto
|PMID=21509519
|Title=Linkage analysis of plasma dopamine beta-hydroxylase activity in families of patients with schizophrenia.
|OA=1
}}

{{PMID Auto
|PMID=23384717
|Title=Association Between 1603C&gt;T Polymorphism of DBH Gene and Bipolar Disorder in a Turkish Population
}}

{{PMID Auto
|PMID=23510745
|Title=Positive association between -1021TT genotype of dopamine beta hydroxylase gene and progressive behavior of injection heroin users
}}

{{PMID Auto
|PMID=23906995
|Title=Association of functional DBH genetic variants with alcohol dependence risk and related depression and suicide attempt phenotypes: Results from a large multicenter association study
}}

{{PMID Auto
|PMID=22875483
|Title=Identification of a novel ANKK1 and other dopaminergic (DRD2 and DBH) gene variants in migraine susceptibility.
}}

{{PMID Auto
|PMID=22906516
|Title=Pharmacogenetic randomized trial for cocaine abuse: disulfiram and dopamine beta-hydroxylase.
|OA=1
}}

{{PMID Auto
|PMID=23261162
|Title=DBH -1021C>T and COMT Val108/158Met genotype are not associated with the P300 ERP in an auditory oddball task.
}}

{{PMID Auto
|PMID=23416088
|Title=Genotype-independent decrease in plasma dopamine beta-hydroxylase activity in Alzheimer's disease.
|OA=1
}}

{{PMID Auto
|PMID=23458673
|Title=DBH gene as predictor of response in a cocaine vaccine clinical trial.
|OA=1
}}

{{PMID Auto
|PMID=23692268
|Title=Association between dopamine Beta-hydroxylase gene polymorphisms and attention-deficit hyperactivity disorder in korean children.
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}