{{Rsnum
|rsid=1613662
|Gene=GP6
|Chromosome=19
|position=55536595
|Orientation=plus
|ReferenceAllele=C
|MissenseAllele=T
|GMAF=0.1309
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=132
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}
{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 68.1 | 25.7 | 6.2
| HCB | 97.1 | 2.9 | 0.0
| JPT | 98.2 | 1.8 | 0.0
| YRI | 58.5 | 36.1 | 5.4
| ASW | 63.2 | 29.8 | 7.0
| CHB | 97.1 | 2.9 | 0.0
| CHD | 97.2 | 2.8 | 0.0
| GIH | 52.5 | 41.6 | 5.9
| LWK | 56.0 | 33.9 | 10.1
| MEX | 86.2 | 12.1 | 1.7
| MKK | 51.9 | 42.9 | 5.1
| TSI | 65.7 | 32.4 | 2.0
| HapMapRevision=28
}}Gene variants associated with [[deep vein thrombosis]].{{PMID|18349091}}

Updated analysis of gene variants associated with [[deep vein thrombosis]].{{PMID|20124536}}

per risk allele odds ratio 
*[[rs13146272]] in CYP4V2 (risk allele frequency, 0.64) OR 1.24 (95% CI, 1.11-1.37) for rs13146272
*[[rs2227589]] in SERPINC1 (risk allele frequency, 0.10) OR 1.29 (95% CI, 1.10-1.49) for rs2227589
*[[rs1613662]] in GP6 (risk allele frequency, 0.84) OR 1.15 (95% CI, 1.01-1.30) for rs1613662

A study of 453 VTE cases and 1,327 controls was able to replicate the "mild effects" of this SNP on risk for VTE, however they felt that stronger associations were found between increased VTE risk and either the Factor V Leiden mutation ([[rs6025]])or having blood types O or A2.{{PMID|19278955}}

{{PMID Auto
|PMID=19786296
|Title=Platelet glycoprotein GP VI 13254C allele is an independent risk factor of premature myocardial infarction
}}

{{PMID Auto
|PMID=22133274
|Title=Polymorphisms of PAI-1 and platelet GP Ia may associate with impairment of renal function and thrombocytopenia in Puumala hantavirus infection
|OA=1
}}

{{PMID|20031567|OA=1
}} An evaluation of candidate genes of inflammation and thrombosis in relation to the risk of venous thromboembolism: The Women's Genome Health Study.

{{PMID|21232005}} New gene variants associated with venous thrombosis: a replication study in White and Black Americans.

{{PMID|21854539}} Genetic determinants of platelet reactivity during acetylsalicylic acid therapy in diabetic patients: evaluation of 27 polymorphisms within candidate genes.

{{GET Evidence
|gene=GP6
|aa_change=Pro219Ser
|aa_change_short=P219S
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1613662
|overall_frequency_n=7986
|overall_frequency_d=9686
|overall_frequency=0.824489
|n_genomes=53
|n_genomes_annotated=0
|n_haplomes=91
|n_articles=0
|n_articles_annotated=0
|nblosum100=3
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=23150947
|Title=Single nucleotide polymorphisms and the risk of venous thrombosis: results from a Danish case-cohort study
}}

{{PMID Auto
|PMID=23168074
|Title=The prevalence of the platelet glycoprotein VI polymorphisms in patients with sticky platelet syndrome and ischemic stroke
}}

{{PMID Auto
|PMID=23739280
|Title=Association study of the platelet collagen receptor glycoprotein VI gene with rheumatoid arthritis
}}

{{PMID Auto
|PMID=22821001
|Title=Variability of GP6 gene in patients with sticky platelet syndrome and deep venous thrombosis and/or pulmonary embolism.
}}

{{PMID Auto
|PMID=22901851
|Title=Platelet aggregation abnormalities in patients with fetal losses: the GP6 gene polymorphism.
}}

{{PMID Auto
|PMID=25091233
|Title=Association of F11 polymorphism rs2289252 with deep vein thrombosis and related phenotypes in population of Latvia
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}