{{Rsnum
|rsid=16139
|Gene=NPY
|Chromosome=7
|position=24285260
|Orientation=minus
|ReferenceAllele=T
|MissenseAllele=C
|GMAF=0.01745
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=NPY
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 87.7 | 12.3 | 0.0
| HCB | 100.0 | 0.0 | 0.0
| JPT | 99.1 | 0.9 | 0.0
| YRI | 99.3 | 0.7 | 0.0
| ASW | 98.2 | 1.8 | 0.0
| CHB | 100.0 | 0.0 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 59.6 | 40.4 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}
{{omim
|desc=NEUROPEPTIDE Y POLYMORPHISM
|id=162640
|rsnum=16139
|variant=0001
}}

{{PharmGKB
|RSID=rs16139
|Name_s=NYP: L7P
|Gene_s=NPY
|Feature=
|Evidence=PubMed ID:15201542; PubMed ID:18499283; PubMed ID:9846584
|Annotation=This non-synonymous variant in the NYP gene was associate with several conditions and diseases in several studies. In obese adults the variant was associates with higher serum levels of total and LDL cholesterol, or in hypertensive subjects with increased risk for myocardial infarction and stroke.The carrier frequency of P7 allele varies from 6% to 15% in the Caucasian populations, and it seems to be totally absent or extremely low in oriental populations.
|Drugs=
|Drug Classes=
|Diseases=Myocardial Infarction
|Curation Level=Curated
|PharmGKB Accession ID=PA161748485
}}

{{ClinVar
|rsid=16139
|Reversed=1
|FwdREF=A
|FwdALT=G
|REF=T
|ALT=C
|RSPOS=24324879
|CHROM=7
|GMAF=0.0174
|dbSNPBuildID=54
|SSR=0
|SAO=1
|VP=0x050068000000150517110101
|GENEINFO=NPY:4852
|GENE_NAME=NPY
|GENE_ID=4852
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000007.13:g.24324879T>C
|CLNORIGIN=1
|CLNSIG=2
|Tags=RV;PM;PMC;VLD;G5;HD;GNO;KGPhase1;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.9826; 0.01745
|CLNACC=RCV000015068.1
|CLNDBN=NEUROPEPTIDE Y POLYMORPHISM
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=162640.0001
|COMMON=1
|Disease=NEUROPEPTIDE Y POLYMORPHISM
}}

{{PMID|17357083|OA=1
}} Medical sequencing at the extremes of human body mass.

{{PMID|18385673|OA=1
}} Genetic variation in human NPY expression affects stress response and emotion.

{{PMID|18828811|OA=1
}} Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence.

{{PMID|19119412|OA=1
}} Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis.

{{PMID|19470168|OA=1
}} NPAS2 and PER2 are linked to risk factors of the metabolic syndrome.

{{PMID|19587357|OA=1
}} A systematic meta-analysis of genetic association studies for diabetic retinopathy.

{{PMID|20180986|OA=1
}} CLOCK is suggested to associate with comorbid alcohol use and depressive disorders.

{{PMID|20351714}} Poor replication of candidate genes for major depressive disorder using genome-wide association data.

{{GET Evidence
|gene=NPY
|aa_change=Leu7Pro
|aa_change_short=L7P
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs16139
|overall_frequency_n=297
|overall_frequency_d=10758
|overall_frequency=0.0276074
|n_genomes=4
|n_genomes_annotated=0
|n_haplomes=3
|n_articles=2
|n_articles_annotated=2
|in_omim=Y
|in_pharmgkb=Y
|pph2_score=0.137
|nblosum100=7
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=22290120
|Title=The evolutionary significance of depression in Pathogen Host Defense (PATHOS-D).
|OA=1
}}

{{PMID Auto
|PMID=23122776
|Title=Neuropeptide Y polymorphism increases the risk for asthma in overweight subjects; protection from atherosclerosis in asthmatic subjects--the cardiovascular risk in young Finns study.
}}

{{PMID Auto
|PMID=25221996
|Title=Association of Neuropeptide Y (NPY), Interleukin-1B (IL1B) Genetic Variants and Correlation of IL1B Transcript Levels with Vitiligo Susceptibility
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}