{{Rsnum
|rsid=16147
|Gene=NPY
|Chromosome=7
|position=24283791
|Orientation=minus
|GMAF=0.4449
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=NPY
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 28.3 | 41.6 | 30.1
| HCB | 10.9 | 44.5 | 44.5
| JPT | 10.6 | 42.5 | 46.9
| YRI | 38.1 | 41.5 | 20.4
| ASW | 40.4 | 47.4 | 12.3
| CHB | 10.9 | 44.5 | 44.5
| CHD | 12.8 | 44.0 | 43.1
| GIH | 25.7 | 53.5 | 20.8
| LWK | 34.5 | 47.3 | 18.2
| MEX | 12.1 | 36.2 | 51.7
| MKK | 23.1 | 60.9 | 16.0
| TSI | 17.6 | 57.8 | 24.5
| HapMapRevision=28
}}{{PMID|18385673|OA=1
}} located in the promoter region alters NPY expression in vitro and seems to account for more than half of the variation in expression in vivo. These convergent findings are consistent with the function of NPY as an anxiolytic peptide and help to explain inter-individual variation in resiliency to [[stress]], a risk factor for many diseases.

{{PMID|19119412|OA=1
}} Risk of Early-Onset [[atherosclerosis]]

{{omim
|desc=NEUROPEPTIDE Y; NPY
|id=162640
|rsnum=16147
}}

{{PMID Auto
|PMID=20037921
|Title=NPY moderates the relation between hurricane exposure and generalized anxiety disorder in an epidemiologic sample of hurricane-exposed adults
|OA=1
}}

{{PMID Auto
|PMID=22584873
|Title=Genetic Variation in the Neuropeptide Y Gene Promoter Is Associated with Increased Risk of Tobacco Smoking
}}

{{PMID Auto
|PMID=22669627
|Title=Polymorphisms in LEP and NPY genes modify the response to soluble fibre Plantago ovata husk intake on cardiovascular risk biomarkers
|OA=1
}}

{{PMID Auto
|PMID=19566775
|Title=Association between neuropeptide Y gene and its receptor Y1 gene and methamphetamine dependence.
}}

{{PMID Auto
|PMID=19854625
|Title=Neuropeptide Y (NPY) gene: Impact on emotional processing and treatment response in anxious depression.
}}

{{PMID Auto
|PMID=20435026
|Title=Age and sex dependent genetic effects of neuropeptide Y promoter polymorphism on susceptibility to ischemic stroke in Koreans.
}}

{{PMID Auto
|PMID=20648632
|Title=Human NPY promoter variation rs16147:T>C as a moderator of prefrontal NPY gene expression and negative affect.
|OA=1
}}

{{PMID Auto
|PMID=21273004
|Title=An interaction between a neuropeptide Y gene polymorphism and early adversity modulates endocrine stress responses.
}}

{{PMID Auto
|PMID=22966009
|Title=Neuropeptide Y Promoter Polymorphism Modifies Effects of a Weight-Loss Diet on 2-Year Changes of Blood Pressure: The Preventing Overweight Using Novel Dietary Strategies Trial
|OA=1
}}

{{PMID Auto
|PMID=23277265
|Title=Association of a Functional Polymorphism in Neuropeptide Y With Antipsychotic-Induced Weight Gain in Schizophrenia Patients
}}

{{PMID Auto
|PMID=23652383
|Title=Functional Polymorphism in the Neuropeptide Y Gene Promoter (rs16147) Is Associated with Serum Leptin Levels and Waist-Hip Ratio in Women
}}

{{PMID Auto
|PMID=22941950
|Title=Increasing association between a neuropeptide Y promoter polymorphism and body mass index during the course of development.
}}

{{PMID Auto
|PMID=23122776
|Title=Neuropeptide Y polymorphism increases the risk for asthma in overweight subjects; protection from atherosclerosis in asthmatic subjects--the cardiovascular risk in young Finns study.
}}

{{PMID Auto
|PMID=23624317
|Title=Influence of variants in the NPY gene on obesity and metabolic syndrome features in Spanish children.
}}

{{PMID Auto
|PMID=24897239
|Title=Association of neuropeptide Y gene rs16147 polymorphism with metabolic syndrome in patients with documented coronary artery disease
}}

{{PMID Auto
|PMID=25081719
|Title=Association of Polymorphisms in Stress-Related TNFα and NPY Genes with the Metabolic Syndrome in Han and Hui Ethnic Groups
}}

{{PMID Auto
|PMID=25221996
|Title=Association of Neuropeptide Y (NPY), Interleukin-1B (IL1B) Genetic Variants and Correlation of IL1B Transcript Levels with Vitiligo Susceptibility
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}