{{Rsnum
|rsid=1617640
|Gene=EPO
|Chromosome=7
|position=100719675
|Orientation=minus
|GMAF=0.3379
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=EPO
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 14.2 | 51.3 | 34.5
| HCB | 4.4 | 31.4 | 64.2
| JPT | 3.5 | 31.0 | 65.5
| YRI | 11.6 | 44.2 | 44.2
| ASW | 12.3 | 47.4 | 40.4
| CHB | 4.4 | 31.4 | 64.2
| CHD | 7.3 | 33.9 | 58.7
| GIH | 18.8 | 43.6 | 37.6
| LWK | 9.1 | 41.8 | 49.1
| MEX | 13.8 | 46.6 | 39.7
| MKK | 5.1 | 32.1 | 62.8
| TSI | 11.8 | 52.9 | 35.3
| HapMapRevision=28
}}

{{PMID|18458324|OA=1
}} the T allele of SNP rs1617640 in the promoter of the EPO gene is significantly associated with Proliferative diabetic retinopathy (PDR) and end stage renal disease (ESRD). The EPO concentration in human vitreous body was 7.5-fold higher in normal subjects with the TT risk genotype than in those with the GG genotype.

{{omim
|desc=MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 2; MVCD2
|id=612623
|rsnum=1617640
}}

{{omim
|id=133170
|desc=ERYTHROPOIETIN; EPO
|rsnum=1617640
}}

{{PharmGKB
|RSID=rs1617640
|Name_s=
|Gene_s=EPO
|Feature=
|Evidence=PubMed ID:18458324
|Annotation=SNP is significantly associated with proliferative diabetic retinopathy and end stage renal disease.
|Drugs=
|Drug Classes=
|Diseases=Diabetic Retinopathy
|Curation Level=Curated
|PharmGKB Accession ID=PA161614166
}}
{{PMID Auto
|PMID=20065225
|Title=Association between erythropoietin gene polymorphisms and diabetic retinopathy
}}

{{PMID Auto
|PMID=21092038
|Title=Relation between renal dysfunction requiring renal replacement therapy and promoter polymorphism of the erythropoietin gene in cardiac surgery
}}

{{omim
|id=133170
|rsnum=1617640
|variant=0001
}}

{{PMID Auto
|PMID=22669473
|Title=Common variants of the genes encoding erythropoietin and its receptor modulate cognitive performance in schizophrenia.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1617640
|overall_frequency_n=84
|overall_frequency_d=126
|overall_frequency=0.666667
|n_genomes=47
|n_genomes_annotated=0
|n_haplomes=71
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23142128
|Title=Association between polymorphisms in erythropoietin gene and upper limit haematocrit levels among regular blood donors
}}

{{PMID Auto
|PMID=22843933
|Title=The functional polymorphism of erythropoietin gene rs1617640 G>T is not associated with susceptibility and clinical outcome of early-stage breast cancer.
}}

{{PMID Auto
|PMID=24821155
|Title=Single nucleotide polymorphisms at erythropoietin, superoxide dismutase 1, splicing factor, arginine/serin-rich 15 and plasmacytoma variant translocation genes association with diabetic nephropathy
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}