{{Rsnum
|rsid=1625579
|Gene=MIR137HG
|Chromosome=1
|position=98037378
|Orientation=minus
|GMAF=0.1882
|Gene_s=MIR137HG
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 69.6 | 27.7 | 2.7
| HCB | 88.3 | 11.7 | 0.0
| JPT | 88.5 | 10.6 | 0.9
| YRI | 45.9 | 44.5 | 9.6
| ASW | 35.1 | 56.1 | 8.8
| CHB | 88.3 | 11.7 | 0.0
| CHD | 88.1 | 11.9 | 0.0
| GIH | 49.5 | 43.6 | 6.9
| LWK | 49.5 | 41.1 | 9.3
| MEX | 82.8 | 15.5 | 1.7
| MKK | 63.5 | 34.0 | 2.6
| TSI | 58.4 | 36.6 | 5.0
| HapMapRevision=28
}}{{PMID|21926974|OA=1
}} [[schizophrenia]], p = 1.6 x 10^-11, top hit in a rather large combined sample of (stage 1) 21,856 Europeans and (stage 2, replication) 29,839 independent individuals, see also [http://www.schizophreniaforum.org/new/detail.asp?id=1629 this post on the Schizophrenia Research Forum]

Per the above reference, this SNP is located within an intron of miR-137 / MIR137 ([[wikipedia:Mir-137|on Wikipedia]]). Four other additional loci containing predictive targets of this [[microRNA]] also passed the threshold for genome-wide significance.. potentially suggesting some involvement of miR-137 mediated activity in the disease.

{{PMID|22733126}} Genome-wide supported variant MIR137 and severe negative symptoms predict membership of an impaired cognitive subtype of schizophrenia.

{{PMID Auto
|PMID=22982201
|Title=Mood congruent psychotic symptoms and specific cognitive deficits in carriers of the novel schizophrenia risk variant at MIR-137
}}

{{PMID Auto
|PMID=22910404
|Title=Genetic association study of the P300 endophenotype in schizophrenia
}}

{{PMID Auto GWAS
  |PMID=23453885
  |Trait=Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined)
  |Title=Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
  |RiskAllele=
  |Pval=2E-11
  |OR=NR
  |ORtxt=NR
  |OA=1
}}

{{PMID Auto
|PMID=23786914
|Title=Analysis of miR-137 expression and rs1625579 in dorsolateral prefrontal cortex
}}

{{PMID Auto
|PMID=22850735
|Title=Impact of a microRNA MIR137 susceptibility variant on brain function in people at high genetic risk of schizophrenia or bipolar disorder.
|OA=1
}}

{{PMID Auto
|PMID=22883350
|Title=Experimental validation of candidate schizophrenia gene ZNF804A as target for hsa-miR-137.
}}

{{PMID Auto
|PMID=23459466
|Title=The genome-wide supported microRNA-137 variant predicts phenotypic heterogeneity within schizophrenia.
}}

{{PMID Auto
|PMID=24820543
|Title=Genome-wide schizophrenia variant at MIR137 does not impact white matter microstructure in healthy participants
}}

{{PMID Auto
|PMID=25084801
|Title=Association of microRNA137 Gene Polymorphisms with Age at Onset and Positive Symptoms of Schizophrenia in a Han Chinese Population
}}

{{PMID Auto
|PMID=25241074
|Title=Lack of association between microRNA-137 SNP rs1625579 and schizophrenia in a replication study of Han Chinese
}}

{{PMID Auto
|PMID=25250332
|Title=Association of a miRNA-137 Polymorphism with Schizophrenia in a Southern Chinese Han Population
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA}}
{{on chip | Illumina Human 1M}}