{{Rsnum
|rsid=16260
|Gene=CDH1
|Chromosome=16
|position=68737131
|Orientation=plus
|GMAF=0.2323
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=CDH1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 4.4 | 46.9 | 48.7
| HCB | 5.1 | 40.1 | 54.7
| JPT | 4.4 | 31.0 | 64.6
| YRI | 2.0 | 25.9 | 72.1
| ASW | 1.8 | 17.5 | 80.7
| CHB | 5.1 | 40.1 | 54.7
| CHD | 8.3 | 35.8 | 56.0
| GIH | 2.0 | 44.6 | 53.5
| LWK | 0.0 | 21.8 | 78.2
| MEX | 6.9 | 29.3 | 63.8
| MKK | 1.9 | 23.7 | 74.4
| TSI | 2.0 | 48.0 | 50.0
| HapMapRevision=28
}}
[PMID 14961571, PMID 16189707] [[rs16260]] (A) SNP located in the promoter region of the E-cadherin [[CDH1]] gene is associated with increased risk of hereditary [[prostate cancer]].

The effect appears to be additive, in that compared to the [[rs16260(C;C)]] homozygotes, the [[rs16260(A;C)]] heterozygotes are at about a 1.5 - 1.7 fold increased risk, and the [[rs16260(A;A)]] homozygotes are at about a 2.6 fold increased risk.

* see also [http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=192090&a=192090_AllelicVariant0018 OMIM 192090.0018]

{{PMID Auto
|PMID=19569232
|Title=The CDH1-160C&gt;A polymorphism is a risk factor for colorectal cancer
}}

{{PMID Auto
|PMID=20044998
|Title=Genetic risk factors for post-infectious irritable bowel syndrome following a waterborne outbreak of gastroenteritis
}}
{{PMID Auto
|PMID=20880515
|Title=Association of CDH1 promoter polymorphism and the risk of non-syndromic orofacial clefts in a Chinese Han population
}}

{{omim
|id=192090
|rsnum=16260
|variant=0018
}}

{{PMID Auto
|PMID=22535324
|Title=CDH1 gene polymorphisms, plasma CDH1 levels and risk of gastric cancer in a Chinese population
}}

{{PMID Auto
|PMID=22792244
|Title=Contribution of the -160C/A Polymorphism in the E-cadherin Promoter to Cancer Risk: A Meta-Analysis of 47 Case-Control Studies
|OA=1
}}

{{PMID Auto
|PMID=14724163
|Title=Analysis of candidate modifier loci for the severity of colonic familial adenomatous polyposis, with evidence for the importance of the N-acetyl transferases.
|OA=1
}}

{{PMID Auto
|PMID=19011631
|Title=Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.
|OA=1
}}

{{PMID Auto
|PMID=19034965
|Title=Genetic determination of irritable bowel syndrome.
|OA=1
}}

{{PMID Auto
|PMID=19551141
|Title=Analysis of germline variants in CDH1, IGFBP3, MMP1, MMP3, STK15 and VEGF in familial and sporadic renal cell carcinoma.
|OA=1
}}

{{PMID Auto
|PMID=19567509
|Title=Genetic variants and prostate cancer risk: candidate replication and exploration of viral restriction genes.
|OA=1
}}

{{PMID Auto
|PMID=19671196
|Title=Absence of germline mono-allelic promoter hypermethylation of the CDH1 gene in gastric cancer patients.
|OA=1
}}

{{PMID Auto
|PMID=20632448
|Title=Association of E-cadherin (CDH1) gene polymorphisms and gastric cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=22330421
|Title=E-cadherin polymorphisms and susceptibility to arsenic-related skin lesions in West Bengal, India.
}}

{{PMID Auto
|PMID=23231047
|Title=Association Between CDH1 and MSX1 Gene Polymorphisms and the Risk of Nonsyndromic Cleft Lip and/or Cleft Palate in a Southeast Iranian Population
}}

{{PMID Auto
|PMID=24023817
|Title=The -160C&gt;A Polymorphism in e-Cadherin Is Associated with the Risk of Nephrolithiasis
|OA=1
}}

{{PMID Auto
|PMID=10706097
|Title=A single nucleotide polymorphism in the E-cadherin gene promoter alters transcriptional activities.
}}

{{PMID Auto
|PMID=24838934
|Title=Nucleotide variants of the cancer predisposing gene CDH1 and the risk of non-syndromic cleft lip with or without cleft palate
}}

{{PMID Auto
|PMID=25150394
|Title=Genetic variation of the E-cadherin gene is associated with primary infertility in patients with ovarian endometriosis
}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}