{{Rsnum
|rsid=1650697
|Gene=DHFR
|Chromosome=5
|position=80654962
|Orientation=minus
|ReferenceAllele=A
|MissenseAllele=G
|GMAF=0.2268
|Gene_s=DHFR,MSH3
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 61.6 | 34.8 | 3.6
| HCB | 34.8 | 51.1 | 14.1
| JPT | 46.9 | 46.0 | 7.1
| YRI | 92.5 | 6.8 | 0.7
| ASW | 77.2 | 22.8 | 0.0
| CHB | 34.8 | 51.1 | 14.1
| CHD | 45.8 | 42.1 | 12.1
| GIH | 46.5 | 42.6 | 10.9
| LWK | 77.1 | 21.1 | 1.8
| MEX | 58.6 | 34.5 | 6.9
| MKK | 74.0 | 24.7 | 1.3
| TSI | 64.0 | 30.0 | 6.0
| HapMapRevision=28
}}

{{Venter SNP
|rsid=1650697
|allele=G
|frequency=0.183
|uid=1103654144837
|type=heterozygous_SNP
|hugo=MSH3
|ensembl gene=ENSG00000113318
|ensembl transcript=ENST00000265081
|sift=TOLERATED
|disease=Defects in MSH3 are a cause of susceptibility to endometrial cancer (MIM:608089).
}}

{{PMID Auto
|PMID=20737570
|Title=Genetic variants in one-carbon metabolism-related genes contribute to NSCLC prognosis in a Chinese population
}}

{{PMID Auto
|PMID=18551366
|Title=Genetic variation in DNA repair pathway genes and premenopausal breast cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=19493349
|Title=118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects.
|OA=1
}}

{{PMID Auto
|PMID=20472929
|Title=Folate pathway enzyme gene polymorphisms and the efficacy and toxicity of methotrexate in psoriatic arthritis.
}}

{{GET Evidence
|gene=MSH3
|aa_change=Ile79Val
|aa_change_short=I79V
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1650697
|overall_frequency_n=5679
|overall_frequency_d=6112
|overall_frequency=0.929156
|n_genomes=5
|n_genomes_annotated=0
|n_haplomes=9
|n_articles=0
|n_articles_annotated=0
|nblosum100=-4
|autoscore=0
|webscore=N
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}