{{Rsnum
|rsid=165599
|Gene=COMT
|Chromosome=22
|position=19969258
|Orientation=plus
|GMAF=0.4656
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=ARVCF,COMT
}}[[anxiety]]-related personality traits, [[ADHD]], [[schizophrenia]]

part of a three marker haplotype [[rs737865]]-[[rs4680]]-[[rs165599]]

epistasis between SNPs in COMT ([[rs2097603]], Val158Met ([[rs4680]]), [[rs165599]]) and polymorphisms in other [[schizophrenia]] susceptibility genes

[[popular in pubmed]]

{{PMID|17547583}} is associated with [[bipolar disorder]] and influences prefrontal aspects of verbal [[memory]] in bipolar patients and healthy controls.

{{PMID Auto
|PMID=19369177
|Title=Association of the 3' Region of COMT with Schizophrenia in Taiwan
}}

{{PMID Auto
|PMID=19077118
|Title=Genetic variants in COMT and neurocognitive impairment in families of patients with schizophrenia
}}
{{PMID Auto
|PMID=19095219
|Title=Variation in catechol-O-methyltransferase is associated with duloxetine response in a clinical trial for major depressive disorder
}}

{{omim
|desc=ALZHEIMER DISEASE; AD
|id=104300
|rsnum=165599
}}

{{omim
|desc=CATECHOL-O-METHYLTRANSFERASE; COMT
|id=116790
|rsnum=165599
}}
{{PMID Auto
|PMID=19605537
|Title=Effects of Catechol-O-Methyltransferase on Normal Variation in the Cognitive Function of Children
|OA=1
}}

{{PharmGKB
|RSID=rs165599
|Name_s=
|Gene_s=COMT, ARVCF
|Feature=
|Evidence=PubMed ID:19451915
|Annotation=In a study of 78 African American and 65 white patients diagnosed with schizophrenia or schizoaffective disorder, this SNP in the COMT gene was found to have significant associations with response to risperidone over 2-12 weeks in both African-American and white patients.
|Drugs=risperidone
|Drug Classes=
|Diseases=Schizophrenia
|Curation Level=Curated
|PharmGKB Accession ID=PA164888988
}}

{{PMID Auto
|PMID=20586531
|Title=The catechol-O-methyl-transferase gene in tardive dyskinesia
}}

{{PharmGKB
|RSID=rs165599
|Name_s=
|Gene_s=COMT, ARVCF
|Feature=
|Evidence=PubMed ID:16876132
|Annotation=This variant may predict a favorable outcome for bupropion treatment for smoking cessation
|Drugs=bupropion
|Drug Classes=
|Diseases=Tobacco Use Disorder
|Curation Level=Curated
|PharmGKB Accession ID=PA162168065
}}

{{PMID Auto
|PMID=21595525
|Title=Sensory gating deficit is associated with catechol-O-methyltransferase polymorphisms in bipolar disorder
}}

{{PMID Auto
|PMID=21934638
|Title=A COMT gene haplotype associated with methamphetamine abuse
}}

{{PMID Auto
|PMID=21940152
|Title=The impact of COMT gene polymorphisms on suicidality in treatment resistant major depressive disorder - A European Multicenter Study
}}

{{PMID Auto
|PMID=15570503
|Title=No evidence for gender-specific sharing of COMT alleles in schizophrenia
}}

{{PMID Auto
|PMID=12802784
|Title=A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain.
|OA=1
}}

{{PMID Auto
|PMID=15098000
|Title=COMT haplotypes suggest P2 promoter region relevance for schizophrenia.
}}

{{PMID Auto
|PMID=15124004
|Title=Variants in the catechol-o-methyltransferase (COMT) gene are associated with schizophrenia in Irish high-density families.
}}

{{PMID Auto
|PMID=15457404
|Title=Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain.
|OA=1
}}

{{PMID Auto
|PMID=15505638
|Title=Separate and interacting effects within the catechol-O-methyltransferase (COMT) are associated with schizophrenia.
}}

{{PMID Auto
|PMID=15635644
|Title=A family based study of catechol-O-methyltransferase (COMT) and attention deficit hyperactivity disorder (ADHD).
}}

{{PMID Auto
|PMID=15931594
|Title=An entropy-based statistic for genomewide association studies.
|OA=1
}}

{{PMID Auto
|PMID=15956988
|Title=COMT polymorphisms and anxiety-related personality traits.
}}

{{PMID Auto
|PMID=15962707
|Title=The differential clinical and neurocognitive profiles of COMT SNP rs165599 genotypes in schizophrenia.
}}

{{PMID Auto
|PMID=16027741
|Title=Catechol-O-methyltransferase haplotypes are associated with psychosis in Alzheimer disease.
}}

{{PMID Auto
|PMID=16232322
|Title=COMT genetic variation confers risk for psychotic and affective disorders: a case control study.
|OA=1
}}

{{PMID Auto
|PMID=16380905
|Title=Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios.
|OA=1
}}

{{PMID Auto
|PMID=16483362
|Title=The quantification of COMT mRNA in post mortem cerebellum tissue: diagnosis, genotype, methylation and expression.
|OA=1
}}

{{PMID Auto
|PMID=16525418
|Title=Association of the Val158Met catechol O-methyltransferase genetic polymorphism with panic disorder.
}}

{{PMID Auto
|PMID=16786032
|Title=Impact of complex genetic variation in COMT on human brain function.
}}

{{PMID Auto
|PMID=16816420
|Title=Nonlinear tests for genomewide association studies.
|OA=1
}}

{{PMID Auto
|PMID=17006672
|Title=Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophrenia.
}}

{{PMID Auto
|PMID=17363961
|Title=Clinical involvement of catechol-O-methyltransferase polymorphisms in schizophrenia spectrum disorders: influence on the severity of psychotic symptoms and on the response to neuroleptic treatment.
}}

{{PMID Auto
|PMID=17427186
|Title=Association analysis of COMT polymorphisms and schizophrenia in a Chinese Han population: a case-control study.
}}

{{PMID Auto
|PMID=17466074
|Title=Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort study.
|OA=1
}}

{{PMID Auto
|PMID=17482701
|Title=No associations exist between five functional polymorphisms in the catechol-O-methyltransferase gene and schizophrenia in a Japanese population.
}}

{{PMID Auto
|PMID=17630406
|Title=Dopamine genes and schizophrenia: case closed or evidence pending?
|OA=1
}}

{{PMID Auto
|PMID=17707347
|Title=Genetic variation in catechol-O-methyltransferase: effects on working memory in schizophrenic patients, their siblings, and healthy controls.
|OA=1
}}

{{PMID Auto
|PMID=17949513
|Title=Association between a common haplotype in the COMT gene region and psychiatric disorders in individuals with 22q11.2DS.
}}

{{PMID Auto
|PMID=17961261
|Title=Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia.
|OA=1
}}

{{PMID Auto
|PMID=18021915
|Title=Genetics and smoking cessation improving outcomes in smokers at risk.
|OA=1
}}

{{PMID Auto
|PMID=18081002
|Title=Association of catechol-O-methyltransferase variants with loudness dependence of auditory evoked potentials.
}}

{{PMID Auto
|PMID=18384078
|Title=Association study of candidate variants of COMT with neuroticism, anxiety and depression.
}}

{{PMID Auto
|PMID=18436194
|Title=Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes.
|OA=1
}}

{{PMID Auto
|PMID=18466879
|Title=Association of a nonsynonymous variant of DAOA with visuospatial ability in a bipolar family sample.
|OA=1
}}

{{PMID Auto
|PMID=18574484
|Title=The complex global pattern of genetic variation and linkage disequilibrium at catechol-O-methyltransferase.
|OA=1
}}

{{PMID Auto
|PMID=18704099
|Title=Association between the catechol-O-methyltransferase Val158Met polymorphism and cocaine dependence.
|OA=1
}}

{{PMID Auto
|PMID=18715757
|Title=Genetic associations with schizophrenia: meta-analyses of 12 candidate genes.
|OA=1
}}

{{PMID Auto
|PMID=19071221
|Title=Impact of interacting functional variants in COMT on regional gray matter volume in human brain.
|OA=1
}}

{{PMID Auto
|PMID=19329282
|Title=Meta-analysis of association between genetic variants in COMT and schizophrenia: an update.
}}

{{PMID Auto
|PMID=19365560
|Title=Low enzymatic activity haplotypes of the human catechol-O-methyltransferase gene: enrichment for marker SNPs.
|OA=1
}}

{{PMID Auto
|PMID=19721400
|Title=Association between COMT gene and Chinese male schizophrenic patients with violent behavior.
}}

{{PMID Auto
|PMID=20080926
|Title=The influence of 5-HTT and COMT genotypes on verbal fluency in ecstasy users.
}}

{{PMID Auto
|PMID=20531207
|Title=The impact of catechol-O-methyltransferase SNPs and haplotypes on treatment response phenotypes in major depressive disorder: a case-control association study.
}}

{{PMID Auto
|PMID=20627703
|Title=The association of single nucleotide polymorphisms in the catechol-O-methyltransferase gene and pain scores in female patients with major depressive disorder.
}}

{{PMID Auto
|PMID=20667552
|Title=Catechol-o-methyltransferase gene modulation on suicidal behavior and personality traits: review, meta-analysis and association study.
}}

{{PMID Auto
|PMID=21172166
|Title=Pharmacogenetics of antidepressant response.
|OA=1
}}

{{PMID Auto
|PMID=21462137
|Title=[An association study of COMT gene polymorphisms with schizophrenia].
}}

{{PMID Auto
|PMID=21609749
|Title=Role of functional dopaminergic gene polymorphisms in the etiology of idiopathic intellectual disability.
}}

{{PMID Auto
|PMID=21788083
|Title=Association of catechol-O-methyltransferase variants with duloxetine response in major depressive disorder.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs165599
|overall_frequency_n=68
|overall_frequency_d=116
|overall_frequency=0.586207
|n_genomes=34
|n_genomes_annotated=0
|n_haplomes=54
|n_articles=2
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=24320736
|Title=Role of single nucleotide polymorphisms in estrogen-metabolizing enzymes and susceptibility to uterine leiomyoma in Han Chinese: A case-control study
}}

{{PMID Auto
|PMID=22713126
|Title=COMT polymorphisms as predictors of cognitive dysfunction during manic and mixed episodes in bipolar I disorder.
}}

{{PMID Auto
|PMID=23178897
|Title=The catechol-O-methyltransferase gene (COMT) and cognitive function from childhood through adolescence.
|OA=1
}}

{{PMID Auto
|PMID=23332465
|Title=Polymorphisms in microRNA target sites influence susceptibility to schizophrenia by altering the binding of miRNAs to their targets
}}

{{PMID Auto
|PMID=23598060
|Title=Association study of polymorphisms in the alpha 7 nicotinic acetylcholine receptor subunit and catechol-o-methyl transferase genes with sensory gating in first-episode schizophrenia
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}