{{Rsnum
|rsid = 165688
|Status = Merged
|Merged = 4680
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Chromosome=22
|position=19963748
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene=COMT
|Gene_s=COMT,MIR4761
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 24.8 | 46.0 | 29.2
| HCB | 10.2 | 37.2 | 52.6
| JPT | 6.2 | 45.5 | 48.2
| YRI | 10.2 | 42.2 | 47.6
| ASW | 12.3 | 29.8 | 57.9
| CHB | 10.2 | 37.2 | 52.6
| CHD | 4.6 | 43.5 | 51.9
| GIH | 21.8 | 42.6 | 35.6
| LWK | 8.3 | 42.2 | 49.5
| MEX | 13.8 | 44.8 | 41.4
| MKK | 8.4 | 37.4 | 54.2
| TSI | 19.6 | 51.0 | 29.4
| HapMapRevision=28
}}{{PMID|18160646}} ([http://genes2brains2mentalhealth.wordpress.com/2008/01/01/sweets-now-sweets-later-rs165688-makes-my-holidays-hell/ via g2b2mh blog]) [[rs165688]] correlated with preferences for immediate reward and brain activation.

{{omim
|id=116790
|desc=CATECHOL-O-METHYLTRANSFERASE; COMT
|rsnum=165688
}}