{{Rsnum
|rsid=1667394
|Gene=HERC2
|Chromosome=15
|position=28285036
|Orientation=minus
|GMAF=0.4582
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=HERC2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 72.1 | 27.0 | 0.9
| HCB | 5.2 | 37.0 | 57.8
| JPT | 7.1 | 27.4 | 65.5
| YRI | 0.0 | 8.8 | 91.2
| ASW | 3.5 | 36.8 | 59.6
| CHB | 5.2 | 37.0 | 57.8
| CHD | 6.5 | 38.3 | 55.1
| GIH | 13.9 | 43.6 | 42.6
| LWK | 0.0 | 4.6 | 95.4
| MEX | 39.7 | 39.7 | 20.7
| MKK | 0.6 | 13.5 | 85.8
| TSI | 35.3 | 45.1 | 19.6
| HapMapRevision=28
}}rs1667394 increases susceptibility to Blond rather than brown hair 4.94 times for carriers of the A allele {{PMID|17952075}}

rs1667394 increases susceptibility to Blue rather than brown eyes 29.43 times for carriers of the A allele {{PMID|17952075}}

rs1667394 increases susceptibility to Blue rather than green eyes 6.74 times for carriers of the A allele {{PMID|17952075}}

For green versus blue [[eye color]]  [[rs12913832]] in OCA2/HERC2 has a score of 51.5 and an estimated allelic OR of 8.43 . The SNP rs1667394 in this same region has an estimated OR of  (4.85–10.06). {{doi|10.1371/journal.pgen.1000993}}

{{omim
|id=605837
|desc=HECT DOMAIN AND RCC1-LIKE DOMAIN 2; HERC2
|rsnum=1667394
}}

{{omim
|id=605837
|rsnum=1667394
|variant=0001
}}

{{PMID Auto
|PMID=18252221
|Title=Three genome-wide association studies and a linkage analysis identify HERC2 as a human iris color gene.
|OA=1
}}

{{PMID Auto
|PMID=18252222
|Title=A single SNP in an evolutionary conserved region within intron 86 of the HERC2 gene determines human blue-brown eye color.
|OA=1
}}

{{PMID Auto
|PMID=18483556
|Title=A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation.
|OA=1
}}

{{PMID Auto
|PMID=20585627
|Title=Web-based, participant-driven studies yield novel genetic associations for common traits.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1667394
|overall_frequency_n=48
|overall_frequency_d=126
|overall_frequency=0.380952
|n_genomes=30
|n_genomes_annotated=0
|n_haplomes=44
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23100201
|Title=A single-nucleotide polymorphism (SNP) multiplex system: the association of five SNPs with human eye and hair color in the Slovenian population and comparison using a Bayesian network and logistic regression model
|OA=1
}}

{{PMID Auto GWAS
  |PMID=23118974
  |Trait=Eye color
  |Title=Genome-wide association studies of quantitatively measured skin, hair, and eye pigmentation in four European populations.
  |RiskAllele=C
  |Pval=2E-20
  |OR=.35
  |ORtxt=[0.28-0.42] unit increase
  |OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}