{{Rsnum
|rsid=167771
|Gene=DRD3
|Chromosome=3
|position=114157428
|Orientation=plus
|GMAF=0.348
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=DRD3
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 67.3 | 28.3 | 4.4
| HCB | 62.8 | 36.5 | 0.7
| JPT | 71.7 | 23.9 | 4.4
| YRI | 2.0 | 21.8 | 76.2
| ASW | 12.3 | 49.1 | 38.6
| CHB | 62.8 | 36.5 | 0.7
| CHD | 66.1 | 30.3 | 3.7
| GIH | 32.7 | 51.5 | 15.8
| LWK | 0.0 | 13.6 | 86.4
| MEX | 44.8 | 48.3 | 6.9
| MKK | 9.0 | 36.5 | 54.5
| TSI | 60.8 | 34.3 | 4.9
| HapMapRevision=28
}}{{PMID|19058789}} [[rs167771]] was significantly associated with [[autism]] spectrum disorder in a study of 144 patients.

{{PMID|19506579}} G allele associated with increased extra-pyramidal symptom risk as a result of [[risperidone]] treatment in a study of 321 psychiatric inpatients (81 presenting with EPS and 189 without)

{{PharmGKB
|RSID=rs167771
|Name_s=rs167771:G>A
|Gene_s=DRD3
|Feature=
|Evidence=PubMed ID:19506579
|Annotation=Risk or phenotype-associated allele: G. Phenotype: The G variant of rs167771 was associated with increased risk for extrapyramidal symptoms in psychiatric patients receiving risperidone. Study size: 132. Study population/ethnicity: Patients with Schizophrenia or Bipolar disorder receiving antipsychotics; Caucasians; Spain; Catalonia. Significance metric(s): OR = 3.3; p = 0.00013. Type of association: PD.
|Drugs=risperidone
|Drug Classes=
|Diseases=Bipolar Disorder; Dyskinesia, Drug-Induced; Dystonia; Hypokinesia; Muscle Rigidity; Schizophrenia; Tremor
|Curation Level=Curated
|PharmGKB Accession ID=PA165109604
}}

{{PMID Auto
|PMID=21691864
|Title=Brief Report: The Dopamine-3-Receptor Gene (DRD3) is Associated with Specific Repetitive Behavior in Autism Spectrum Disorder (ASD)
|OA=1
}}

{{PMID Auto
|PMID=22309839
|Title=Association study of 45 candidate genes in nicotine dependence in Han Chinese
}}

{{PMID Auto
|PMID=18330705
|Title=Physiogenomic analysis of localized FMRI brain activity in schizophrenia.
|OA=1
}}

{{PMID Auto
|PMID=20148275
|Title=Shared heritability of attention-deficit/hyperactivity disorder and autism spectrum disorder.
|OA=1
}}

{{PMID Auto
|PMID=20619616
|Title=Searching for functional SNPs or rare variants in exonic regions of DRD3 in risperidone-treated patients.
}}

{{PMID Auto
|PMID=22397633
|Title=Neurotransmitter systems and neurotrophic factors in autism: association study of 37 genes suggests involvement of DDC.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs167771
|overall_frequency_n=78
|overall_frequency_d=128
|overall_frequency=0.609375
|n_genomes=41
|n_genomes_annotated=0
|n_haplomes=67
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}