{{Rsnum
|rsid=16847548
|Chromosome=1
|position=162065484
|Orientation=plus
|GMAF=0.2447
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 0.0 | 26.6 | 73.4
| HCB | 11.1 | 55.6 | 33.3
| JPT | 24.4 | 42.2 | 33.3
| YRI | 6.3 | 33.3 | 60.3
| ASW | 0.0 | 0.0 | 0.0
| CHB | 11.1 | 55.6 | 33.3
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{PMID|19180230|OA=1
}} [[rs16847548]] and  [[rs16856785]] strongly associated with QT interval

{{PMID|19204306|OA=1
}} Based on a large study of 19,000+ adults, SNPs [[rs10494366]], [[rs4657139]] and [[rs16847548]] were significantly associated with adjusted QT interval in whites but not in African-Americans. The relative hazard of [[sudden cardiac death]] (SCD) associated with each [[rs16847548]](C) allele was 1.31 (CI: 1.10 - 1.56, p=0.002). [[rs12567209]] was also independently associated with SCD in whites (relative hazard 0.57, CI: 0.39 - 0.83, p=0.003).

{{PMID Auto
|PMID=20538168
|Title=Polymorphisms in the NOS1AP Gene Modulate QT Interval Duration and Risk of Arrhythmias in the Long QT Syndrome
}}

{{PMID Auto
|PMID=19822806
|Title=NOS1AP is a genetic modifier of the long-QT syndrome.
|OA=1
}}

{{PMID Auto
|PMID=24096169
|Title=Single nucleotide polymorphisms in arrhythmia genes modify the risk of cardiac events and sudden death in long QT syndrome
}}

{{PMID Auto
|PMID=22708720
|Title=Identification of a novel KCNQ1 mutation in a large Saudi family with long QT syndrome: clinical consequences and preventive implications.
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}