{{Rsnum
|rsid=16892496
|Gene=TRHR
|Chromosome=8
|position=109097622
|Orientation=plus
|GMAF=0.3485
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=TRHR
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 41.6 | 51.3 | 7.1
| HCB | 32.1 | 45.3 | 22.6
| JPT | 23.9 | 56.6 | 19.5
| YRI | 66.7 | 29.3 | 4.1
| ASW | 50.9 | 38.6 | 10.5
| CHB | 32.1 | 45.3 | 22.6
| CHD | 30.3 | 52.3 | 17.4
| GIH | 35.6 | 41.6 | 22.8
| LWK | 60.9 | 34.5 | 4.5
| MEX | 29.3 | 46.6 | 24.1
| MKK | 53.8 | 37.8 | 8.3
| TSI | 57.8 | 37.3 | 4.9
| HapMapRevision=28
}}{{PMID Auto
|PMID=19268274
|Title=Genome-wide Association and Replication Studies Identified TRHR as an Important Gene for Lean Body Mass.
|OA=1
}}

{{omim
|desc=LEAN BODY MASS QUANTITATIVE TRAIT LOCUS 1; LBMQTL1
|id=612729
|rsnum=16892496
}}

{{PharmGKB
|RSID=rs16892496
|Name_s=
|Gene_s=TRHR
|Feature=
|Evidence=PubMed ID:19268274
|Annotation=In a genome-wide association study performed in 1000 unrelated US Whites, this SNP was significantly associated with Lean Body Mass(p=7.55 x 10 -8). Subjects carrying the GG genotype at this SNP averaged 2.70 kg higher Lean Body Mass than subjects carrying TT or GT genotypes. The significant association was replicated in 1488 unrelated US Whites, in 2955 unrelated Chinese, and in 593 nuclear families of 1972 US Whites.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA164918076
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs16892496
|overall_frequency_n=41
|overall_frequency_d=128
|overall_frequency=0.320312
|n_genomes=29
|n_genomes_annotated=0
|n_haplomes=37
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23543262
|Title=Association between polymorphisms in the TRHR gene, fat-free mass, and muscle strength in older women.
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}