{{Rsnum
|rsid=16892766
|Chromosome=8
|position=116618444
|Orientation=plus
|GMAF=0.07208
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 78.8 | 21.2 | 0.0
| HCB | 99.3 | 0.7 | 0.0
| JPT | 100.0 | 0.0 | 0.0
| YRI | 65.3 | 33.3 | 1.4
| ASW | 86.0 | 14.0 | 0.0
| CHB | 99.3 | 0.7 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 95.0 | 5.0 | 0.0
| LWK | 82.7 | 16.4 | 0.9
| MEX | 91.4 | 6.9 | 1.7
| MKK | 82.7 | 13.5 | 3.8
| TSI | 84.3 | 14.7 | 1.0
| HapMapRevision=28
}}

{{GWAS Summary
|SNP=rs16892766
|PubMedID=18372905
|Condition=Colorectal cancer
|Gene=EIF3H
|Risk Allele=A
|pValue=3.00E-018
|OR=1.27
|95CI=1.20-1.34
}}

{{omim
|desc=COLORECTAL CANCER, SUSCEPTIBILITY TO, 6; CRCS6
|id=612231
|rsnum=16892766
}}
{{PMID Auto
|PMID=19843678
|Title=Enrichment of Low Penetrance Susceptibility Loci in a Dutch Familial Colorectal Cancer Cohort
}}

{{PharmGKB
|RSID=rs16892766
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18372905; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: A genome-wide association study identifies colorectal cancer susceptibility loci on chromosome 10p14 and 8q23.3 (Initial Sample Size: 922 cases, 927 controls; Replication Sample Size: 17,872 cases, 17,526 controls; Risk Allele: rs16892766-A).
|Drugs=
|Drug Classes=
|Diseases=Colorectal Neoplasms
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356770
}}

{{PMID Auto
|PMID=20638935
|Title=Susceptibility Genetic Variants Associated With Colorectal Cancer Risk Correlate With Cancer Phenotype
}}
{{PMID Auto
|PMID=21097774
|Title=Colorectal cancer susceptibility loci on chromosome 8q23.3 and 11q23.1 as modifiers for disease expression in lynch syndrome
}}
{{PMID Auto
|PMID=21119214
|Title=Colorectal Cancer Susceptibility Loci in a Population-Based Study: Associations with Morphological Parameters
|OA=1
}}

{{PMID Auto GWAS
|PMID=21761138
|Trait=None
|Title=Meta-analysis of new genome-wide association studies of colorectal cancer risk.
|RiskAllele=
|Pval=4E-7
|OR=1.2400
|ORtxt=[1.14-1.34]
|OA=1
}}

{{PMID Auto
|PMID=22367214
|Title=Characterization of gene-environment interactions for colorectal cancer susceptibility loci
|OA=1
}}

{{PMID Auto
|PMID=22532847
|Title=Pooled Sample-Based GWAS: A Cost-Effective Alternative for Identifying Colorectal and Prostate Cancer Risk Variants in the Polish Population
|OA=1
}}

{{PMID Auto
|PMID=19010329
|Title=Chromosome 8q23.3 and 11q23.1 variants modify colorectal cancer risk in Lynch syndrome.
}}

{{PMID Auto
|PMID=19011631
|Title=Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.
|OA=1
}}

{{PMID Auto
|PMID=20501757
|Title=Low-penetrance susceptibility variants in familial colorectal cancer.
|OA=1
}}

{{PMID Auto
|PMID=20648012
|Title=Association studies on 11 published colorectal cancer risk loci.
|OA=1
}}

{{PMID Auto
|PMID=21071539
|Title=Generalizability and epidemiologic characterization of eleven colorectal cancer GWAS hits in multiple populations.
|OA=1
}}

{{PMID Auto
|PMID=21314996
|Title=Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci.
|OA=1
}}

{{PMID Auto
|PMID=22045029
|Title=Relationship between 16 susceptibility loci and colorectal cancer phenotype in 3146 patients.
}}

{{PMID Auto
|PMID=22235025
|Title=Susceptibility genetic variants associated with early-onset colorectal cancer.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs16892766
|overall_frequency_n=13
|overall_frequency_d=128
|overall_frequency=0.101562
|n_genomes=10
|n_genomes_annotated=0
|n_haplomes=10
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
|n_web_uneval=10
}}

{{PMID Auto
|PMID=23359760
|Title=Single-nucleotide polymorphism associations for colorectal cancer in southern chinese population
|OA=1
}}

{{PMID Auto
|PMID=22848671
|Title=Association of eleven common, low-penetrance colorectal cancer susceptibility genetic variants at six risk loci with clinical outcome.
|OA=1
}}

{{PMID Auto
|PMID=22987364
|Title=Combined analysis of three Lynch syndrome cohorts confirms the modifying effects of 8q23.3 and 11q23.1 in MLH1 mutation carriers.
}}

{{PMID Auto
|PMID=22999960
|Title=Much of the genetic risk of colorectal cancer is likely to be mediated through susceptibility to adenomas.
|OA=1
}}

{{PMID Auto
|PMID=23434150
|Title=Are the common genetic variants associated with colorectal cancer risk for DNA mismatch repair gene mutation carriers?
|OA=1
}}

{{PMID Auto
|PMID=24875374
|Title=Variation in the Association Between Colorectal Cancer Susceptibility Loci and Colorectal Polyps by Polyp Type
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}