{{Rsnum
|rsid=16901979
|Chromosome=8
|position=127112671
|Orientation=plus
|GMAF=0.18
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Summary=risk for prostate cancer
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 0.0 | 6.2 | 93.8
| HCB | 6.6 | 38.0 | 55.5
| JPT | 0.9 | 33.6 | 65.5
| YRI | 33.3 | 49.0 | 17.7
| ASW | 5.3 | 54.4 | 40.4
| CHB | 6.6 | 38.0 | 55.5
| CHD | 6.4 | 43.1 | 50.5
| GIH | 2.0 | 23.8 | 74.3
| LWK | 23.6 | 51.8 | 24.5
| MEX | 0.0 | 6.9 | 93.1
| MKK | 6.4 | 42.9 | 50.6
| TSI | 0.0 | 8.8 | 91.2
| HapMapRevision=28
}}{{CPMC SNP
|link=http://cpmc.coriell.org/Sections/Genes/CAD.aspx?PgId=186
}}

[[rs16901979]] is a SNP on chromosome 8q24, associated with increased risk for [[prostate cancer]] in several studies. In some studies, the regions have been divided, and this SNP falls in region 2.

In a study of over 3,600 Caucasians with [[prostate cancer]], [[rs16901979]] is one of five SNPs used (with family history as a sixth factor) to cumulatively predict overall risk. On their own, the [[rs16901979]](A;A) and (A;C) risk genotypes yield an odds ratio for developing [[prostate cancer]] of 1.53 (CI: 1.22-1.92, p=1.8x10e-4) and may account for 3.6% of population attributable risk.{{doi|10.1056/NEJMoa075819}}

cancer related according to this [http://cancergenetics.wordpress.com/2007/08/07/association-with-prostate-and-colon-cancer-8q24/ blog]

Two genetic markers in the 8q24 region of chromosome 8 [[rs7008482]] and [[rs16901979]] have been linked to an increased risk of [[prostate cancer]] in African Americans. [http://www.genome.org/cgi/content/abstract/gr.6782707v1 abstract]

In follow-up studies looking at disease severity (and not just overall risk), this SNP is reported to account for the risk (from region 2) of advanced [[prostate cancer]].{{PMID|18231127|OA=1
}}

A meta-analysis of 10+ studies comprising over 15,000 [[prostate cancer]] patients concluded that the odds ratio for [[rs16901979]](A) allele carriers is 1.74 (CI: 1.72-1.77).{{PMID|18231127|OA=1
}}

{{GWAS Summary
|SNP=rs16901979
|PubMedID=17401366
|Condition=Prostate cancer
|Gene=Intergenic
|Risk Allele=A
|pValue=1.00E-012
|OR=1.79
|95CI=1.53-2.11) (EA
}}
{{ neighbor
| rsid = 10505483
| distance = 279
}}

{{PMID Auto
|PMID=19549807
|Title=Prostate Cancer Risk Associated Loci in African Americans
|OA=1
}}
{{PMID Auto
|PMID=19562729
|Title=Common variants in 8q24 are associated with risk for prostate cancer and tumor aggressiveness in men of European ancestry
|OA=1
}}

{{omim
|desc=PROSTATE CANCER, HEREDITARY, 10; HPC10
|id=611100
|rsnum=16901979
}}
{{PMID Auto GWAS
|PMID=19767754
|Trait=Prostate cancer
|Title=Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility
|RiskAllele=A
|Pval=3E-14
|OR=1.80
|ORtxt=[1.55-2.09]
|OA=1
}}
{{PMID Auto
|PMID=19908238
|Title=Common variants at 8q24 are associated with prostate cancer risk in Taiwanese men
}}

{{PharmGKB
|RSID=rs16901979
|Name_s=
|Gene_s=SRRM1L
|Feature=
|Evidence=PubMed ID:17401366; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24 (Initial Sample Size: 1,435 cases, 3,064 controls; Replication Sample Size: 1,210 EA cases, 2,445 EA controls; 373 AA cases, 372 AA controls; Risk Allele: rs16901979-A).
|Drugs=
|Drug Classes=
|Diseases=Prostatic Neoplasms
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356603
}}

{{PMID Auto
|PMID=20564319
|Title=Prostate cancer risk-associated variants reported from genome-wide association studies: Meta-analysis and their contribution to genetic Variation
|OA=1
}}
{{PMID Auto
|PMID=20717903
|Title=Evidence for an association between prostate cancer and chromosome 8q24 and 10q11 genetic variants in African American men: The flint men's health study
}}
{{PMID Auto
|PMID=21229559
|Title=Chromosome 8q24 variants are associated with prostate cancer risk in a high risk population of African ancestry
}}

{{PMID Auto
|PMID=21820706
|Title=Prostate Cancer Risk Alleles and Their Associations With Other Malignancies
|OA=1
}}

{{PMID Auto
|PMID=21756274
|Title=Systematic confirmation study of reported prostate cancer risk-associated single nucleotide polymorphisms in Chinese men
|OA=1
}}

{{PMID Auto
|PMID=22067658
|Title=Networks of intergenic long-range enhancers and snpRNAs drive castration-resistant phenotype of prostate cancer and contribute to pathogenesis of multiple common human disorders
|OA=1
}}

{{PMID Auto
|PMID=22234922
|Title=8q24 risk alleles in West African and Caribbean men
|OA=1
}}

{{PMID Auto
|PMID=22303333
|Title=Replication of GWAS "Hits" by Race for Breast and Prostate Cancers in European Americans and African Americans
|OA=1
}}

{{PMID Auto
|PMID=22583965
|Title=Association of common variations of 8q24 with the risk of prostate cancer in Koreans and a review of the Asian population
}}

{{PMID Auto
|PMID=17978284
|Title=Confirmation study of prostate cancer risk variants at 8q24 in African Americans identifies a novel risk locus.
|OA=1
}}

{{PMID Auto
|PMID=18213635
|Title=Chromosome 8q24 risk variants in hereditary and non-hereditary prostate cancer patients.
}}

{{PMID Auto
|PMID=18274536
|Title=Genome-wide association studies: progress and potential for drug discovery and development.
|OA=1
}}

{{PMID Auto
|PMID=18360876
|Title=Chromosome 8q24 markers: risk of early-onset and familial prostate cancer.
|OA=1
}}

{{PMID Auto
|PMID=18423739
|Title=Tumor characteristics of carriers and noncarriers of the deCODE 8q24 prostate cancer susceptibility alleles.
}}

{{PMID Auto
|PMID=18491292
|Title=Cumulative effect of five genetic variants on prostate cancer risk in multiple study populations.
|OA=1
}}

{{PMID Auto
|PMID=18577746
|Title=Multiple loci with different cancer specificities within the 8q24 gene desert.
|OA=1
}}

{{PMID Auto
|PMID=18670647
|Title=Homozygous deletions and recurrent amplifications implicate new genes involved in prostate cancer.
|OA=1
}}

{{PMID Auto
|PMID=18682823
|Title=Canadian Urological Association, 63rd Annual Meeting, Edmonton, AB, June 22-25, 2008.
|OA=1
}}

{{PMID Auto
|PMID=18768484
|Title=Family-based samples can play an important role in genetic association studies.
|OA=1
}}

{{PMID Auto
|PMID=18768513
|Title=Common 8q24 sequence variations are associated with Asian Indian advanced prostate cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=18794092
|Title=Association of prostate cancer risk variants with clinicopathologic characteristics of the disease.
|OA=1
}}

{{PMID Auto
|PMID=18990762
|Title=Associations between variants of the 8q24 chromosome and nine smoking-related cancer sites.
|OA=1
}}

{{PMID Auto
|PMID=19058137
|Title=Clinical utility of five genetic variants for predicting prostate cancer risk and mortality.
|OA=1
}}

{{PMID Auto
|PMID=19104501
|Title=Prostate cancer genomics: towards a new understanding.
|OA=1
}}

{{PMID Auto
|PMID=19434657
|Title=Individual and cumulative effect of prostate cancer risk-associated variants on clinicopathologic variables in 5,895 prostate cancer patients.
|OA=1
}}

{{PMID Auto
|PMID=19520795
|Title=Novel single nucleotide polymorphism associations with colorectal cancer on chromosome 8q24 in African and European Americans.
|OA=1
}}

{{PMID Auto
|PMID=19528667
|Title=Association of chromosome 8q variants with prostate cancer risk in Caucasian and Hispanic men.
|OA=1
}}

{{PMID Auto
|PMID=19602258
|Title=Significance of common variants on human chromosome 8q24 in relation to the risk of prostate cancer in native Japanese men.
|OA=1
}}

{{PMID Auto
|PMID=20039378
|Title=Estimation of genotype relative risks from pedigree data by retrospective likelihoods.
|OA=1
}}

{{PMID Auto
|PMID=20133699
|Title=Long-range enhancers on 8q24 regulate c-Myc.
|OA=1
}}

{{PMID Auto
|PMID=20584312
|Title=8q24 sequence variants in relation to prostate cancer risk among men of African descent: a case-control study.
|OA=1
}}

{{PMID Auto
|PMID=20690139
|Title=Meta-analysis of genome-wide and replication association studies on prostate cancer.
}}

{{PMID Auto
|PMID=20823317
|Title=is-rSNP: a novel technique for in silico regulatory SNP detection.
|OA=1
}}

{{PMID Auto
|PMID=21390317
|Title=Characterizing associations and SNP-environment interactions for GWAS-identified prostate cancer risk markers--results from BPC3.
|OA=1
}}

{{PMID Auto
|PMID=21445969
|Title=Significant associations of prostate cancer susceptibility variants with survival in patients treated with androgen-deprivation therapy.
}}

{{PMID Auto
|PMID=21455501
|Title=Genetic variants on chromosome 8q24 and colorectal neoplasia risk: a case-control study in China and a meta-analysis of the published literature.
|OA=1
}}

{{PMID Auto
|PMID=21557270
|Title=Chromosome 8q24 variants are associated with prostate cancer risk in a high risk population of African ancestry.
}}

{{PMID Auto
|PMID=22382457
|Title=Racial disparities in the association between variants on 8q24 and prostate cancer: a systematic review and meta-analysis.
|OA=1
}}

{{PMID Auto
|PMID=22561070
|Title=8q24 and 17q Prostate cancer susceptibility loci in a multiethnic Asian cohort().
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs16901979
|overall_frequency_n=26
|overall_frequency_d=128
|overall_frequency=0.203125
|n_genomes=21
|n_genomes_annotated=0
|n_haplomes=29
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23405784
|Title=[Susceptibility to prostate cancer in Han Chinese: single nucleotide polymorphism analysis of 1 667 cases]
}}

{{PMID Auto
|PMID=24345439
|Title=Prostate cancer risk alleles are associated with prostate cancer tumor volume and prostate size
}}

{{PMID Auto
|PMID=22848662
|Title=Polymorphisms on 8q24 are associated with lung cancer risk and survival in Han Chinese.
|OA=1
}}

{{PMID Auto
|PMID=22848671
|Title=Association of eleven common, low-penetrance colorectal cancer susceptibility genetic variants at six risk loci with clinical outcome.
|OA=1
}}

{{PMID Auto
|PMID=25252079
|Title=8q24 risk alleles and prostate cancer in African-Barbadian men
}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Affy500k}}