{{Rsnum
|rsid=16906252
|Gene=MGMT
|Chromosome=10
|position=131265545
|Orientation=minus
|ReferenceAllele=C
|GMAF=0.02709
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}
{{PMID|17621591}} strongly associated with MGMT methylation (multivariate odds ratio 18.0; 95% confidence interval, 6.2-52.1, P < 0.0001) and loss of MGMT expression in [[colorectal cancer]] tumors

{{ neighbor
| rsid = 12269324
| distance = 925
}}

{{PMID Auto
|PMID=19789298
|Title=Detection of MGMT Promoter Methylation in Normal Individuals Is Strongly Associated with the T Allele of the rs16906252 MGMT Promoter Single Nucleotide Polymorphism
}}

{{PMID Auto
|PMID=19734844
|Title=MGMT methylation is associated primarily with the germline C&gt;T SNP (rs16906252) in colorectal cancer and normal colonic mucosa
}}

{{PMID Auto
|PMID=20627446
|Title=Methylation of MGMT in malignant pleural mesothelioma occurs in a subset of patients and is associated with the T allele of the rs16906252 MGMT promoter SNP.
}}

{{PMID Auto
|PMID=21355081
|Title=The A/G allele of rs16906252 predicts for MGMT methylation and is selectively silenced in premalignant lesions from smokers and in lung adenocarcinomas.
|OA=1
}}

{{PMID Auto
|PMID=22975219
|Title=The T genotype of the MGMT C&gt;T (rs16906252) enhancer single-nucleotide polymorphism (SNP) is associated with promoter methylation and longer survival in glioblastoma patients
}}

{{PMID Auto
|PMID=24380367
|Title=Epigenetic modulation of the drug resistance genes MGMT, ABCB1 and ABCG2 in glioblastoma multiforme
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}