{{Rsnum
|rsid=1693482
|Gene=ADH1C
|Chromosome=4
|position=99342808
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.2397
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|effect1=
|effect2=
|effect3=
|Gene_s=ADH1C
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 30.2 | 44.4 | 25.4
| HCB | 95.5 | 4.5 | 0.0
| JPT | 83.7 | 16.3 | 0.0
| YRI | 88.5 | 11.5 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 95.5 | 4.5 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[[rs1693482]], also known as Arg272Gln, is a SNP in the alcohol dehydrogenase 1C [[ADH1C]] gene. The [[rs1693482]](C) allele is the more common, encoding the amino acid arginine (Arg); the rarer [[rs1693482]](T) allele encodes the variant glutamine (Gln). 

A study of 575 Irish alcoholics observed an association between [[rs1693482]] and risk for [[alcohol dependence]].{{PMID|18331377|OA=1
}}

On it's own, this SNP is also said to explain 8.4% of the variability in the rate at which alcohol is metabolized, based on a study of 250 Spaniards.{{PMID|20101753}}

More significantly (in a statistical sense), this study concluded that combinations of this SNP and others were shown to affect alcohol metabolism; most of these combinations are represented by the [[gs211]]
genoset.

Note that the effects of alcohol are higher in individuals who break down (basically, detoxify) ethanol more slowly.

{{omim
|id=103730
|desc=ALCOHOL DEHYDROGENASE 1C, GAMMA POLYPEPTIDE; ADH1C
|rsnum=1693482
}}

{{PMID Auto
|PMID=19861527
|Title=Impact of multiple alcohol dehydrogenase gene polymorphisms on risk of upper aerodigestive tract cancers in a Japanese population
}}

{{omim
|id=103730
|rsnum=1693482
|variant=0001
}}

{{ClinVar
|rsid=1693482
|Reversed=0
|FwdREF=C
|FwdALT=T
|REF=C
|ALT=T
|RSPOS=100263965
|CHROM=4
|GMAF=0.2395
|dbSNPBuildID=89
|SSR=0
|SAO=1
|VP=0x050378000000150517110100
|GENEINFO=ADH1C:126
|GENE_NAME=ADH1C
|GENE_ID=126
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000004.11:g.100263965C>T
|CLNSRC=OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=103730.0001
|CLNSIG=255
|CLNCUI=CN028882
|CLNDBN=Alcohol dependence
|Disease=Alcohol dependence
|CLNACC=RCV000019810.1
|Tags=PM;TPA;PMC;S3D;SLO;VLD;G5;HD;GNO;KGPhase1;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.7603; 0.2397
|CLNDSDB=MedGen:OMIM
|CLNDSDBID=CN028882:103780
|COMMON=1
}}

{{PMID Auto
|PMID=16018848
|Title=Influence of alcohol dehydrogenase 1C polymorphism on the alcohol-cardiovascular disease association (from the Framingham Offspring Study).
}}

{{PMID Auto
|PMID=16685648
|Title=Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence.
|OA=1
}}

{{PMID Auto
|PMID=17185388
|Title=Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans.
|OA=1
}}

{{PMID Auto
|PMID=17273965
|Title=Evidence of positive selection on a class I ADH locus.
|OA=1
}}

{{PMID Auto
|PMID=18936436
|Title=Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994.
|OA=1
}}

{{PMID Auto
|PMID=18996923
|Title=Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis.
|OA=1
}}

{{PMID Auto
|PMID=19193628
|Title=ADH single nucleotide polymorphism associations with alcohol metabolism in vivo.
|OA=1
}}

{{PMID Auto
|PMID=19379518
|Title=Development of a fingerprinting panel using medically relevant polymorphisms.
|OA=1
}}

{{PMID Auto
|PMID=19526455
|Title=ADH1A variation predisposes to personality traits and substance dependence.
|OA=1
}}

{{PMID Auto
|PMID=20700531
|Title=The association of alcohol and alcohol metabolizing gene variants with diabetes and coronary heart disease risk factors in a white population.
|OA=1
}}

{{PMID Auto
|PMID=21303386
|Title=Alcohol-metabolizing enzyme gene polymorphisms in the Basque Country, Morocco, and Ecuador.
}}

{{GET Evidence
|gene=ADH1C
|aa_change=Arg271Gln
|aa_change_short=R271Q
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1693482
|overall_frequency_n=3218
|overall_frequency_d=10758
|overall_frequency=0.299126
|n_genomes=23
|n_genomes_annotated=0
|n_haplomes=26
|n_articles=0
|n_articles_annotated=0
|nblosum100=0
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=22560290
|Title=A comparison of Val81Met and other polymorphisms of alcohol metabolising genes in patients and controls in Northern Spain.
}}

{{PMID Auto
|PMID=23404349
|Title=Childhood acute leukemia, maternal beverage intake during pregnancy, and metabolic polymorphisms.
}}

{{on chip | 23andMe v3}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}