{{Rsnum
|rsid=16947078
|Gene=TBX21
|Chromosome=17
|position=47748134
|Orientation=plus
|GMAF=0.146
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 61.9 | 35.4 | 2.7
| HCB | 97.1 | 2.9 | 0.0
| JPT | 97.3 | 2.7 | 0.0
| YRI | 59.2 | 39.5 | 1.4
| ASW | 70.2 | 29.8 | 0.0
| CHB | 97.1 | 2.9 | 0.0
| CHD | 98.2 | 1.8 | 0.0
| GIH | 77.2 | 20.8 | 2.0
| LWK | 72.7 | 24.5 | 2.7
| MEX | 67.2 | 32.8 | 0.0
| MKK | 60.3 | 37.8 | 1.9
| TSI | 61.8 | 25.5 | 12.7
| HapMapRevision=28
}}
A large study of Caucasian children has identified this SNP in the [[TBX21]] gene (and one other, [[rs11650354]]) as defining a haplotype associated with increased risk for allergic [[asthma]]. {{PMID|17949803}}

The odds ratio associated with [[rs16947078]](G;G) homozygotes compared to [[rs16947078]](A;A) homozygotes for allergic [[asthma]] is reported to be 8.13 (CI: 2.5-26.9). Heterozygotes may be at slightly higher risk. {{PMID|17949803}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}