{{Rsnum
|rsid=1695
|Gene=GSTP1
|Chromosome=11
|position=67585218
|Orientation=plus
|ReferenceAllele=A
|MissenseAllele=G
|GMAF=0.3246
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Summary=influences asthma risk
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=GSTP1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 31.9 | 54.9 | 13.3
| HCB | 65.4 | 32.4 | 2.2
| JPT | 83.2 | 15.9 | 0.9
| YRI | 35.4 | 49.7 | 15.0
| ASW | 29.8 | 52.6 | 17.5
| CHB | 65.4 | 32.4 | 2.2
| CHD | 65.1 | 32.1 | 2.8
| GIH | 43.6 | 48.5 | 7.9
| LWK | 22.7 | 55.5 | 21.8
| MEX | 22.4 | 44.8 | 32.8
| MKK | 40.4 | 46.8 | 12.8
| TSI | 48.0 | 44.1 | 7.8
| HapMapRevision=28
}}This SNP, in the [[GSTP1]] gene influences [[asthma]] risk; the (A) allele encodes the Ile, while the (G) allele encodes the Val. This SNP is also known as GSTP1Val105, or GSTP1 Ile105Val.

Despite evidence of antioxidant effects of vitamin E in vitro and in animal studies, large, randomized clinical trials have not substantiated a benefit of vitamin E in reducing inflammation in humans. In healthy control subjects, the effect of α-tocopherol supplementation on the production of inflammatory cytokines appears to be dependent on an individual's genotype. These genotype-specific differences may help explain some of the discordant results in studies that used vitamin E. Persons having the alleles AA or AG had an increase in interleukin-6 (IL-6) upon supplementing alpha-tocopherol (the most common form of Vitamin E in a North American diet) while those with GG saw a decrease. {{PMID|22572643}}

This [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16882827&query_hl=1&itool=pubmed_docsum research paper] shows that 13- to 21-year-olds exposed to tobacco smoke at home, with this mutation had more severe [[asthma]] than those without the mutation. [[rs1695]] is also mentioned in this [http://news.bbc.co.uk/2/hi/uk_news/scotland/tayside_and_central/5251968.stm bbc article]

Several papers published findings associating GSTP1 Ile105Val genotypes with bronchial, childhood, or atopic asthma. {{PMID|15612961}}

Note that some studies, however, have not observed any association between this SNP and asthma in certain populations {{PMID|16176403}}, or even more paradoxically, have observed that [[rs1695]](G;G) homozygotes appear to be somewhat protected (OR 0.29) from developing asthma compared to individuals with [[rs1695]](A;G) or (A;A) genotypes. {{PMID|14748821|OA=1
}}

A cohort of 1,610 children in the US were studied to determine that the risk for new-onset [[asthma]] was highest in [[rs1695]](A;A) homozygotes who participated in 3 or more sports in high-ozone communities. These children were at 6x higher risk (CI: 2.2-7.4). {{PMID|18988661|OA=1
}}

A study of 3,000 Chinese women with [[breast cancer]] concluded that [[rs1695]](G;G) genotype was significantly associated with greater breast cancer risk, particularly in premenopausal women (odds ratio 1.69, CI: 1.17-2.43). The odds increased further if such women reported eating little cruciferous vegetables (then the odds ratio was 2.08, CI: 1.20-3.59).{{PMID|18326615}}

A relatively small study of 58 patients with different types of [[cancer]] receiving [[docetaxel]] concluded that [[rs1695]](A;A) homozygotes (i.e. Ile105/Ile105 homozygotes) had a higher risk of developing docetaxel-induced peripheral neuropathy (DIPN), particularly grade 2 or higher. The odds ratio reported was 6.1 (CI: 1.17-31.9, p=0.03).{{PMID|19223573}}

{{PMID Auto
|PMID=19383894
|Title=Genetic Polymorphisms in the Catechol Estrogen Metabolism Pathway and Breast Cancer Risk
|OA=1
}}

{{PMID Auto
|PMID=19403501
|Title=In Utero Smoke Exposure, Glutathione S-Transferase P1 Haplotypes, and Respiratory Illness-Related Absence Among Schoolchildren
}}

{{PMID Auto
|PMID=19921428
|Title=Pooled analysis indicates that the GSTT1 deletion, GSTM1 deletion, and GSTP1 Ile105Val polymorphisms do not modify breast cancer risk in BRCA1 and BRCA2 mutation carriers
|OA=1
}}

{{PharmGKB
|RSID=rs1695
|Name_s=GSTP1:Ile105Val; rs1695:A>G
|Gene_s=GSTP1
|Feature=Exon/NonSyn
|Evidence=PubMed ID:19786980
|Annotation=In a study of ovarian cancer patients (n=104) receiving a cisplatin-cyclophosphamide regimen, the Ile/Ile (G/G) genotype of GSTP1:Ile105Val was associated with increased progression free survival.
|Drugs=cisplatin; cyclophosphamide
|Drug Classes=
|Diseases=Ovarian Neoplasms
|Curation Level=Curated
|PharmGKB Accession ID=PA165107196
}}

{{PMID Auto
|PMID=20472488
|Title=GST polymorphisms, interaction with smoking and pesticide use, and risk for Parkinson's disease in a Japanese population
}}

{{PharmGKB
|RSID=rs1695
|Name_s=GSTP1:I105V; GSTP1:A313G; GSTP1*2; Part of haplotypes GSTP1*B and GSTP1*C
|Gene_s=GSTP1
|Feature=Exon/NonSyn
|Evidence=PubMed ID:17180579; PubMed ID:17532303; PubMed ID:17617021; PubMed ID:17642299
|Annotation=Well studied variant for risk of many different cancers and environmental chemical metabolism.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA161145081
}}

{{PharmGKB
|RSID=rs1695
|Name_s=GSTP1: I105V; GSTP1*B
|Gene_s=GSTP1
|Feature=Exon/NonSyn
|Evidence=Web Resource:http://www.pharmgkb.org/search/annotatedGene/gstp1/variant.jsp
|Annotation=The non-synonymous SNP has been associated with reduced enzyme activity and anticancer drug resistance and toxicity.
|Drugs=cisplatin; cyclophosphamide; doxorubicin; etoposide; oxaliplatin; pyrimethamine
|Drug Classes=
|Diseases=
|Curation Level=In-Depth
|PharmGKB Accession ID=PA161845838
}}

{{PharmGKB
|RSID=rs1695
|Name_s=GSTP1:Ile105Val
|Gene_s=GSTP1
|Feature=Exon/NonSyn
|Evidence=PubMed ID:18540691
|Annotation=Elderly rectal cancer patients homozygous for the G (Val) allele of this SNP were less likely than those homozygous for the A (Ile) allele to experience hematological toxicity associated with chemoradiotherapy.
|Drugs=fluorouracil
|Drug Classes=
|Diseases=Drug Toxicity
|Curation Level=Curated
|PharmGKB Accession ID=PA162355826
}}

{{PMID Auto
|PMID=21320344
|Title=Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population
|OA=1
}}

{{PMID Auto
|PMID=20938339
|Title=Temozolomide-induced severe myelosuppression: analysis of clinically associated polymorphisms in two patients
}}

{{PMID Auto
|PMID=21164266
|Title=Glucocorticoid resistance
}}

{{PMID Auto
|PMID=21567099
|Title=Estrogen metabolism genotypes, use of long-term hormone replacement therapy and risk of postmenopausal breast cancer
}}

{{PMID Auto
|PMID=21723269
|Title=Genetic profiling of GSTP1, DPYD, FCGR2A, FCGR3A and CCND1 genes in an Argentinian population
}}

{{PMID Auto
|PMID=22052985
|Title=Glutathione S-transferase P1 c.313A &gt; G polymorphism could be useful in the prediction of doxorubicin response in breast cancer patients
}}

{{PMID Auto
|PMID=22216261
|Title=Association of a Deletion of GSTT2B with an Altered Risk of Oesophageal Squamous Cell Carcinoma in a South African Population: A Case-Control Study
|OA=1
}}

{{PMID Auto
|PMID=21914837
|Title=Childhood brain tumors and maternal cured meat consumption in pregnancy: differential effect by glutathione S-transferases
|OA=1
}}

{{PMID Auto
|PMID=22795327
|Title=Selected polymorphisms of GSTP1 and TERT were associated with glioma risk in Han Chinese
}}

{{PMID Auto
|PMID=15726497
|Title=Gene-environment interaction effects on the development of immune responses in the 1st year of life.
|OA=1
}}

{{PMID Auto
|PMID=16112301
|Title=NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses.
|OA=1
}}

{{PMID Auto
|PMID=17054776
|Title=The genetics of chronic obstructive pulmonary disease.
|OA=1
}}

{{PMID Auto
|PMID=17160896
|Title=Orofacial cleft risk is increased with maternal smoking and specific detoxification-gene variants.
|OA=1
}}

{{PMID Auto
|PMID=17194543
|Title=Glutathione S-transferase mu, omega, pi, and theta class variants and smoking in Parkinson's disease.
|OA=1
}}

{{PMID Auto
|PMID=17366837
|Title=Genetic studies of a cluster of acute lymphoblastic leukemia cases in Churchill County, Nevada.
|OA=1
}}

{{PMID Auto
|PMID=17424838
|Title=[Genetic polymorphisms of MPO, NQO1, GSTP1, UGT1A6 associated with susceptibility of chronic benzene poisoning].
}}

{{PMID Auto
|PMID=17498780
|Title=The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers.
}}

{{PMID Auto
|PMID=17548691
|Title=Associations between smoking, polymorphisms in polycyclic aromatic hydrocarbon (PAH) metabolism and conjugation genes and PAH-DNA adducts in prostate tumors differ by race.
|OA=1
}}

{{PMID Auto
|PMID=17601350
|Title=A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.
|OA=1
}}

{{PMID Auto
|PMID=17885617
|Title=Genetic polymorphisms and benzene metabolism in humans exposed to a wide range of air concentrations.
}}

{{PMID Auto
|PMID=18182569
|Title=Pharmacogenetics of minimal residual disease response in children with B-precursor acute lymphoblastic leukemia: a report from the Children's Oncology Group.
|OA=1
}}

{{PMID Auto
|PMID=18191955
|Title=Correlating observed odds ratios from lung cancer case-control studies to SNP functional scores predicted by bioinformatic tools.
|OA=1
}}

{{PMID Auto
|PMID=18335111
|Title=Glutathione S-transferase P1, maternal smoking, and asthma in children: a haplotype-based analysis.
|OA=1
}}

{{PMID Auto
|PMID=18547414
|Title=Genotyping panel for assessing response to cancer chemotherapy.
|OA=1
}}

{{PMID Auto
|PMID=18559526
|Title=Glutathione s-transferase p1: gene sequence variation and functional genomic studies.
|OA=1
}}

{{PMID Auto
|PMID=18601742
|Title=Polymorphisms of selected xenobiotic genes contribute to the development of papillary thyroid cancer susceptibility in Middle Eastern population.
|OA=1
}}

{{PMID Auto
|PMID=18628428
|Title=Polymorphisms in genes involved in sex hormone metabolism, estrogen plus progestin hormone therapy use, and risk of postmenopausal breast cancer.
|OA=1
}}

{{PMID Auto
|PMID=18709160
|Title=Interactions between glutathione S-transferase P1, tumor necrosis factor, and traffic-related air pollution for development of childhood allergic disease.
|OA=1
}}

{{PMID Auto
|PMID=18776599
|Title=Susceptibility genes for gentamicin-induced vestibular dysfunction.
|OA=1
}}

{{PMID Auto
|PMID=18784359
|Title=Polymorphisms in phase I and phase II metabolism genes and risk of chronic benzene poisoning in a Chinese occupational population.
}}

{{PMID Auto
|PMID=18787887
|Title=Genetic variation in candidate osteoporosis genes, bone mineral density, and fracture risk: the study of osteoporotic fractures.
|OA=1
}}

{{PMID Auto
|PMID=18805939
|Title=Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.
|OA=1
}}

{{PMID Auto
|PMID=18854777
|Title=Germline genetic variations in drug action pathways predict clinical outcomes in advanced lung cancer treated with platinum-based chemotherapy.
|OA=1
}}

{{PMID Auto
|PMID=18992148
|Title=Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study.
|OA=1
}}

{{PMID Auto
|PMID=19076156
|Title=Polymorphisms of drug-metabolizing enzymes (GST, CYP2B6 and CYP3A) affect the pharmacokinetics of thiotepa and tepa.
|OA=1
}}

{{PMID Auto
|PMID=19124514
|Title=Urinary isothiocyanates; glutathione S-transferase M1, T1, and P1 polymorphisms; and risk of colorectal cancer: the Multiethnic Cohort Study.
|OA=1
}}

{{PMID Auto
|PMID=19131562
|Title=Biomarkers of human exposure to acrylamide and relation to polymorphisms in metabolizing genes.
|OA=1
}}

{{PMID Auto
|PMID=19174490
|Title=Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women.
|OA=1
}}

{{PMID Auto
|PMID=19223546
|Title=Xenobiotic metabolizing gene variants, dietary heterocyclic amine intake, and risk of prostate cancer.
|OA=1
}}

{{PMID Auto
|PMID=19258736
|Title=Glutathione s-transferase variants in a brazilian population.
}}

{{PMID Auto
|PMID=19267064
|Title=[Relationship between genetic polymorphisms of phase I and phase II metabolizing enzymes and DNA damage of workers exposed to vinyl chloride monomer].
}}

{{PMID Auto
|PMID=19338043
|Title=Genetic polymorphisms in glutathione S-transferases and cytochrome P450s, tobacco smoking, and risk of non-Hodgkin lymphoma.
|OA=1
}}

{{PMID Auto
|PMID=19498054
|Title=Prenatal tobacco smoke exposure affects global and gene-specific DNA methylation.
|OA=1
}}

{{PMID Auto
|PMID=19568750
|Title=MRP2 and GSTP1 polymorphisms and chemotherapy response in advanced non-small cell lung cancer.
|OA=1
}}

{{PMID Auto
|PMID=19899130
|Title=Polymorphisms of drug-metabolizing genes and risk of non-Hodgkin lymphoma.
}}

{{PMID Auto
|PMID=20049130
|Title=Black carbon exposure, oxidative stress genes, and blood pressure in a repeated-measures study.
|OA=1
}}

{{PMID Auto
|PMID=20049212
|Title=Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS).
|OA=1
}}

{{PMID Auto
|PMID=20091863
|Title=Genetic polymorphisms of MPO, GSTT1, GSTM1, GSTP1, EPHX1 and NQO1 as risk factors of early-onset lung cancer.
}}

{{PMID Auto
|PMID=20233420
|Title=Cluster analysis in severe emphysema subjects using phenotype and genotype data: an exploratory investigation.
|OA=1
}}

{{PMID Auto
|PMID=20445800
|Title=Genetic Polymorphisms in Genes Related to Oxidative Stress (GSTP1, GSTM1, GSTT1, CAT, MnSOD, MPO, eNOS) and Survival of Rectal Cancer Patients after Radiotherapy.
|OA=1
}}

{{PMID Auto
|PMID=20459744
|Title=Cyclophosphamide-metabolizing enzyme polymorphisms and survival outcomes after adjuvant chemotherapy for node-positive breast cancer: a retrospective cohort study.
|OA=1
}}

{{PMID Auto
|PMID=20540773
|Title=The 341C/T polymorphism in the GSTP1 gene is associated with increased risk of oesophageal cancer.
|OA=1
}}

{{PMID Auto
|PMID=20597111
|Title=Effect of interactions of glutathione S-transferase T1, M1, and P1 and HMOX1 gene promoter polymorphisms with heavy smoking on the risk of rheumatoid arthritis.
|OA=1
}}

{{PMID Auto
|PMID=20663217
|Title=Genetic Polymorphisms of CYP2E1, GSTP1, NQO1 and MPO and the Risk of Nasopharyngeal Carcinoma in a Han Chinese Population of Southern China.
|OA=1
}}

{{PMID Auto
|PMID=21595856
|Title=Genetic polymorphisms in antioxidative enzymes are associated to forced expiratory volume in 1 s (FEV1) in smokers independently of asthma.
}}

{{PMID Auto
|PMID=21669193
|Title=GSTP1 mRNA expression in human circulating blood leukocytes is associated with GSTP1 genetic polymorphism.
}}

{{PMID Auto
|PMID=21741876
|Title=Polymorphisms in tobacco metabolism and DNA repair genes modulate oral precancer and cancer risk.
}}

{{PMID Auto
|PMID=22251241
|Title=Role of glutathione S-transferases in melanoma susceptibility: association with GSTP1 rs1695 polymorphism.
}}

{{PMID Auto
|PMID=22475179
|Title=Polymorphisms in genes encoding interleukin-10 and drug metabolizing enzymes GSTP1, GSTT1, GSTA1 and UGT1A1 influence risk and outcome in Hodgkin lymphoma.
}}

{{PMID Auto
|PMID=22525558
|Title=Genetic polymorphisms involved in carcinogen metabolism and DNA repair and lung cancer risk in a Japanese population.
}}

{{PMID Auto
|PMID=22531667
|Title=PM10-induced hospital admissions for asthma and chronic obstructive pulmonary disease: the modifying effect of individual characteristics.
}}

{{PMID Auto
|PMID=22661588
|Title=Antioxidant enzyme polymorphisms and neuropsychological outcomes in medulloblastoma survivors: a report from the Childhood Cancer Survivor Study.
|OA=1
}}

{{GET Evidence
|gene=GSTP1
|aa_change=Ile105Val
|aa_change_short=I105V
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=recessive
|quality_scores=Array
|dbsnp_id=rs1695
|overall_frequency_n=3710
|overall_frequency_d=10318
|overall_frequency=0.359566
|n_genomes=25
|n_genomes_annotated=0
|n_haplomes=29
|n_articles=2
|n_articles_annotated=2
|in_pharmgkb=Y
|nblosum100=-4
|autoscore=1
|webscore=N
|summary_short=Hematological toxicity with fluoruracil.
}}

{{PMID Auto
|PMID=23136956
|Title=The role of Glutathione S-Transferase (GST) and Claudin-1 (CLDN1) gene polymorphisms in contact sensitization: a cross-sectional study
}}

{{PMID Auto
|PMID=23146971
|Title=Glutathione-S-transferase (GST) polymorphisms are associated with relapse after radical prostatectomy
|OA=1
}}

{{PMID Auto
|PMID=24083102
|Title=Associations between null mutations in GSTT1 and GSTM1, the GSTP1 Ile(105)Val polymorphism, and mortality in breast cancer survivors
|OA=1
}}

{{PMID Auto
|PMID=24367646
|Title=Novel single nucleotide polymorphism markers for low dose aspirin-associated small bowel bleeding
|OA=1
}}

{{PMID Auto
|PMID=24423050
|Title=Associations between GSTM1*0 and GSTA1*A genotypes with the risk of cardiovascular death among hemodialyses patients
|OA=1
}}

{{PMID Auto
|PMID=24453034
|Title=Association study of SNPs of genes IFNGR1 (rs137854905), GSTT1 (rs71748309), and GSTP1 (rs1695) in gastric cancer development in samples of patient in the northern and northeastern Brazil
}}

{{PMID Auto
|PMID=24465030
|Title=GSTP1 and TNF Gene Variants and Associations between Air Pollution and Incident Childhood Asthma: The Traffic, Asthma and Genetics (TAG) Study
|OA=1
}}

{{PMID Auto
|PMID=24610081
|Title=Associations Between SNPs Within Antioxidant Genes and the Risk of Prostate Cancer in the Siberian Region of Russia
}}

{{PMID Auto
|PMID=22487578
|Title=Association of glutathione S-transferase pi isoform single-nucleotide polymorphisms with exudative age-related macular degeneration in a Chinese population.
}}

{{PMID Auto
|PMID=22517484
|Title=Clinical significance of SOD2 and GSTP1 gene polymorphisms in Chinese patients with gastric cancer.
}}

{{PMID Auto
|PMID=22610343
|Title=Genetic variants in antioxidant genes are associated with diisocyanate-induced asthma.
|OA=1
}}

{{PMID Auto
|PMID=22735619
|Title=Sample-to-SNP kit: a reliable, easy and fast tool for the detection of HFE p.H63D and p.C282Y variations associated to hereditary hemochromatosis.
}}

{{PMID Auto
|PMID=22868256
|Title=A prospective validation pharmacogenomic study in the adjuvant setting of colorectal cancer patients treated with the 5-fluorouracil/leucovorin/oxaliplatin (FOLFOX4) regimen.
|OA=1
}}

{{PMID Auto
|PMID=23000097
|Title=Polymorphisms of catechol estrogens metabolism pathway genes and breast cancer risk in Mexican women.
}}

{{PMID Auto
|PMID=23065688
|Title=Glutathione S-transferase P1 single nucleotide polymorphism predicts permanent ototoxicity in children with medulloblastoma.
|OA=1
}}

{{PMID Auto
|PMID=23175176
|Title=Variation in PAH-related DNA adduct levels among non-smokers: the role of multiple genetic polymorphisms and nucleotide excision repair phenotype.
}}

{{PMID Auto
|PMID=23333443
|Title=Analysis of polymorphisms and haplotypes in genes associated with vascular tone, hypertension and oxidative stress in Mexican-Mestizo women with severe preeclampsia.
}}

{{PMID Auto
|PMID=23812950
|Title=Pharmacogenetic influence of GST polymorphisms on anthracycline-based chemotherapy responses and toxicity in breast cancer patients: a multi-analytical approach.
}}

{{PMID Auto
|PMID=24786234
|Title=HapMap-based study on the association between MPO and GSTP1 gene polymorphisms and lung cancer susceptibility in Chinese Han population
}}

{{PMID Auto
|PMID=24902621
|Title=Deletion polymorphism of GSTT1 gene as protective marker for allergic rhinitis
}}

{{PMID Auto
|PMID=24919441
|Title=Polymorphisms of NRF2 and NRF2 target genes in urinary bladder cancer patients
}}

{{PMID Auto
|PMID=25008867
|Title=Pharmacogenetic association between GSTP1 genetic polymorphism and febrile neutropenia in Japanese patients with early breast cancer
}}

{{PMID Auto
|PMID=25188725
|Title=Dual Glutathione S-transferase theta 1 (GSTT1) and mu 1 (GSTM1) gene deletions determine imatinib failure in chronic myeloid leukaemia
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}