{{Rsnum
|rsid=16965867
|Gene=DPEP1
|Chromosome=16
|position=89614460
|Orientation=plus
|GMAF=0.1575
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=DPEP1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 76.1 | 23.0 | 0.9
| HCB | 94.9 | 5.1 | 0.0
| JPT | 92.0 | 8.0 | 0.0
| YRI | 59.2 | 34.7 | 6.1
| ASW | 54.4 | 38.6 | 7.0
| CHB | 94.9 | 5.1 | 0.0
| CHD | 90.8 | 9.2 | 0.0
| GIH | 34.7 | 54.5 | 10.9
| LWK | 52.7 | 36.4 | 10.9
| MEX | 70.7 | 27.6 | 1.7
| MKK | 59.0 | 34.0 | 7.1
| TSI | 59.8 | 36.3 | 3.9
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs16965867
|Name_s=
|Gene_s=DPEP1
|Feature=
|Evidence=PubMed ID:17537913
|Annotation=Risk or phenotype-associated allele: not stated Phenotype: Using a Quantitative Transmission Disequilibrium Test (QTDT), this variant was significantly associated with etoposide toxicity based upon IC50 values in cell lines from 30 parent-child trios in combined Caucasian/Yoruban populations (p = 0.00003), and in Caucasians alone (p = 0.00005). In combination, rs10018204, rs11222869, rs16965867, rs1846644, and rs6539870 were significant predictors of etoposide IC50, accounting for 55% of the etoposide IC50 variation in Caucasians. In combination, rs460869, rs6588131, and rs16965867 were all significant predictors of etoposide IC50, accounting for 30% of the variation in etoposide IC50 in the combined populations fo Caucasians and Yorubans. Study size: 176. Study population/ethnicity: 87 European descent Caucasians and 89 Yorubans. Significance metric(s): p = 0.00003. Type of association: FA; GN.
|Drugs=etoposide
|Drug Classes=
|Diseases=Drug Toxicity
|Curation Level=Curated
|PharmGKB Accession ID=PA165109374
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs16965867
|overall_frequency_n=31
|overall_frequency_d=126
|overall_frequency=0.246032
|n_genomes=27
|n_genomes_annotated=0
|n_haplomes=32
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}