{{Rsnum
|rsid=16991615
|Gene=MCM8
|Chromosome=20
|position=5967581
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.03489
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=MCM8
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 0.9 | 16.8 | 82.3
| HCB | 0.0 | 0.0 | 100.0
| JPT | 0.0 | 0.0 | 100.0
| YRI | 0.0 | 0.0 | 100.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 0.0 | 0.0 | 100.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 4.0 | 96.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 10.3 | 89.7
| MKK | 0.0 | 0.0 | 0.0
| TSI | 2.0 | 9.8 | 88.2
| HapMapRevision=28
}}

[[rs16991615]] is a nonsynonymous SNP on chromosome 20.

A case control study of ~2,000 women found that each [[rs16991615]](A) allele was associated with an average increase in age at [[menopause]] of 11 months. This also meant that each [[rs16991615]](G) allele yielded an odds ratio of 1.85 (CI: 1.51–2.2, p = 1.45 x 10e-9) of early menopause, defined as occurring before the age of 46.{{PMID|20952801|OA=1
}}

Overall, women homozygous for the "early" alleles at all 4 SNPs found in this study were ~4 times more likely to undergo menopause early compared to women who had a total of 3 or less risk alleles. However, the ability to predict which women will actually undergo early menopause using these 4 SNPs is still low.{{PMID|20952801|OA=1
}}

* see also [http://blog.23andme.com/2009/05/18/snpwatch-researchers-link-common-genetic-variations-to-those-changes-a-womans-body-goes-through/ 23andMe blog]

{{PMID Auto GWAS
|PMID=19448621
|Trait=Menarche and menopause (age at onset)
|Title=Genome-wide association studies identify loci associated with age at menarche and age at natural menopause
|RiskAllele=A
|Pval=1E-21
|OR=1.07
|ORtxt=[0.85-1.29] years older
|OA=1
}}

{{omim
|id=612885
|rsnum=16991615
}}

{{PMID Auto GWAS
|PMID=22267201
|Trait=None
|Title=Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.
|RiskAllele=A
|Pval=0
|OR=0.9480
|ORtxt=None
|OA=1
}}

{{PMID Auto
|PMID=18535201
|Title=A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose.
|OA=1
}}

{{PMID Auto
|PMID=19664201
|Title=Genetic and genomic insights into age at natural menopause.
|OA=1
}}

{{GET Evidence
|gene=MCM8
|aa_change=Glu341Lys
|aa_change_short=E341K
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs16991615
|overall_frequency_n=534
|overall_frequency_d=10758
|overall_frequency=0.0496375
|n_genomes=4
|n_genomes_annotated=0
|n_haplomes=4
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|pph2_score=0.028
|nblosum100=0
|autoscore=2
|webscore=N
|n_web_uneval=7
}}

{{PMID Auto
|PMID=23508249
|Title=Replication of genetic loci for ages at menarche and menopause in the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) study
}}

{{PMID Auto
|PMID=23592221
|Title=Shared genetic factors for age at natural menopause in Iranian and European women
}}

{{PMID Auto GWAS
  |PMID=23307926
  |Trait=Menopause (age at onset)
  |Title=A genome-wide association study of early menopause and the combined impact of identified variants.
  |RiskAllele=A
  |Pval=5E-12
  |OR=.46
  |ORtxt=[0.33-0.59] years decrease
  |OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}