{{Rsnum
|rsid=16996148
|Gene=CILP2
|Chromosome=19
|position=19547663
|Orientation=plus
|GMAF=0.101
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 82.0 | 17.1 | 0.9
| HCB | 89.6 | 9.6 | 0.7
| JPT | 76.1 | 21.2 | 2.7
| YRI | 81.4 | 17.2 | 1.4
| ASW | 76.8 | 21.4 | 1.8
| CHB | 89.6 | 9.6 | 0.7
| CHD | 87.7 | 12.3 | 0.0
| GIH | 81.2 | 18.8 | 0.0
| LWK | 69.4 | 25.9 | 4.6
| MEX | 87.7 | 12.3 | 0.0
| MKK | 76.8 | 20.6 | 2.6
| TSI | 90.2 | 8.8 | 1.0
| HapMapRevision=28
}}{{GWAS Summary
|SNP=rs16996148
|PubMedID=18193043
|Condition=Triglycerides
|Gene=NCAN,CILP2
|Risk Allele=G
|pValue=3.00E-009
|OR=6.1
|95CI=NR) mg/dl highe
}}

{{PMID Auto GWAS
|PMID=18193044
|Trait=LDL cholesterol
|Title=Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
|RiskAllele=G
|Pval=2.9999999999999997E-8
|OR=0.10
|ORtxt=[0.06-0.14] % SD lower
|OA=1
}}

{{PharmGKB
|RSID=rs16996148
|Name_s=
|Gene_s=CILP2
|Feature=
|Evidence=PubMed ID:18193043; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Newly identified loci that influence lipid concentrations and risk of coronary artery disease (Initial Sample Size: 8,589 individuals; Replication Sample Size: 7,440-10,783 individuals; Risk Allele: rs16996148-G). This variant is associated with LDL cholesterol levels.
|Drugs=
|Drug Classes=
|Diseases=Cardiovascular Diseases; Coronary Disease
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356705
}}

{{PharmGKB
|RSID=rs16996148
|Name_s=
|Gene_s=CILP2
|Feature=
|Evidence=PubMed ID:18193044; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans (Initial Sample Size: 2,758 individuals; Replication Sample Size: 18,544 individuals; Risk Allele: rs16996148-G). This variant is associated with triglyceride levels.
|Drugs=
|Drug Classes=
|Diseases=Cardiovascular Diseases; Coronary Disease
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356717
}}

{{PharmGKB
|RSID=rs16996148
|Name_s=
|Gene_s=CILP2
|Feature=
|Evidence=PubMed ID:18193044; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans (Initial Sample Size: 2,758 individuals; Replication Sample Size: 18,544 individuals; Risk Allele: rs16996148-G). This variant is associated with LDL levels.
|Drugs=
|Drug Classes=
|Diseases=Cardiovascular Diseases; Coronary Disease
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356716
}}

{{PharmGKB
|RSID=rs16996148
|Name_s=
|Gene_s=CILP2
|Feature=
|Evidence=PubMed ID:18193043; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Newly identified loci that influence lipid concentrations and risk of coronary artery disease (Initial Sample Size: 8,684 individuals; Replication Sample Size: 5,312-9,707 individuals; Risk Allele: rs16996148-G). This variant is associated with triglyceride levels.
|Drugs=
|Drug Classes=
|Diseases=Cardiovascular Diseases; Coronary Disease
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356706
}}

{{PMID Auto
|PMID=21823004
|Title=Effects of SNPs at newly identified lipids loci on blood lipid levels and risk of coronary heart disease in Chinese Han population: A case control study
}}

{{PMID Auto
|PMID=18852197
|Title=Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.
|OA=1
}}

{{PMID Auto
|PMID=18987386
|Title=Polymorphisms at newly identified lipid-associated loci are associated with blood lipids and cardiovascular disease in an Asian Malay population.
}}

{{PMID Auto
|PMID=19060910
|Title=Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
|OA=1
}}

{{PMID Auto
|PMID=19060911
|Title=Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
|OA=1
}}

{{PMID Auto
|PMID=19197348
|Title=Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
|OA=1
}}

{{PMID Auto
|PMID=19435741
|Title=Common lipid-altering gene variants are associated with therapeutic intervention thresholds of lipid levels in older people.
|OA=1
}}

{{PMID Auto
|PMID=19656773
|Title=A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia.
|OA=1
}}

{{PMID Auto
|PMID=19951432
|Title=Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.
|OA=1
}}

{{PMID Auto
|PMID=21691831
|Title=Triglyceride level-influencing functional variants of the ANGPTL3, CILP2, and TRIB1 loci in ischemic stroke.
}}

{{PMID Auto
|PMID=22208664
|Title=Sex-specific association of rs16996148 SNP in the NCAN/CILP2/PBX4 and serum lipid levels in the Mulao and Han populations.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs16996148
|overall_frequency_n=18
|overall_frequency_d=128
|overall_frequency=0.140625
|n_genomes=13
|n_genomes_annotated=0
|n_haplomes=13
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23098650
|Title=Impact of variants within seven candidate genes on statin treatment efficacy
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}