{{Rsnum
|rsid=1701704
|Chromosome=12
|position=56018703
|Orientation=minus
|GMAF=0.2397
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene=IKZF4
|Gene_s=IKZF4
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 49.6 | 37.2 | 13.3
| HCB | 61.3 | 32.1 | 6.6
| JPT | 58.4 | 39.8 | 1.8
| YRI | 85.7 | 14.3 | 0.0
| ASW | 71.9 | 26.3 | 1.8
| CHB | 61.3 | 32.1 | 6.6
| CHD | 60.6 | 34.9 | 4.6
| GIH | 67.3 | 24.8 | 7.9
| LWK | 88.2 | 11.8 | 0.0
| MEX | 63.8 | 31.0 | 5.2
| MKK | 65.4 | 30.8 | 3.8
| TSI | 46.1 | 47.1 | 6.9
| HapMapRevision=28
}}

{{GWAS Summary
|SNP=rs1701704
|PubMedID=18198356
|Condition=Type 1 diabetes
|Gene=RAB5B, SUOX, IKZF4, ERBB3, CDK2
|Risk Allele=C
|pValue=9.00E-010
|OR=1.25
|95CI=1.12-1.40
}}

{{PharmGKB
|RSID=rs1701704
|Name_s=
|Gene_s=IKZF4
|Feature=
|Evidence=PubMed ID:18198356; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study (Initial Sample Size: 563 cases, 1,146 controls, 483 trios; Replication Sample Size: 549 families, 1092 individuals from 364 trios; Risk Allele: rs1701704-C).
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus; Diabetes Mellitus, Type 1
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356730
}}

{{PMID Auto GWAS
|PMID=20596022
|Trait=Alopecia areata
|Title=Genome-wide association study in alopecia areata implicates both innate and adaptive immunity
|RiskAllele=C
|Pval=3E-8
|OR=1.34
|ORtxt=[1.21-1.48]
|OA=1
}}

{{PMID Auto GWAS
|PMID=21804548
|Trait=None
|Title=Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population.
|RiskAllele=G
|Pval=2E-13
|OR=1.1900
|ORtxt=[1.14-1.25]
}}

{{PMID Auto GWAS
|PMID=21829393
|Trait=None
|Title=Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
|RiskAllele=T
|Pval=5E-18
|OR=1.2500
|ORtxt=[NR]
|OA=1
}}

{{PMID Auto
|PMID=18840781
|Title=Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=20668683
|Title=Genetically dependent ERBB3 expression modulates antigen presenting cell function and type 1 diabetes risk.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1701704
|overall_frequency_n=25
|overall_frequency_d=128
|overall_frequency=0.195312
|n_genomes=20
|n_genomes_annotated=0
|n_haplomes=20
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23721563
|Title=Associations of polymorphisms in non-HLA loci with autoantibodies at the diagnosis of type 1 diabetes: INS and IKZF4 associate with insulin autoantibodies
}}

{{PMID Auto
|PMID=23028483
|Title=Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}