{{Rsnum
|rsid=17070145
|Gene=WWC1
|Chromosome=5
|position=168418786
|Orientation=plus
|GMAF=0.455
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=WWC1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 46.9 | 42.5 | 10.6
| HCB | 6.6 | 38.0 | 55.5
| JPT | 1.8 | 30.1 | 68.1
| YRI | 10.9 | 45.6 | 43.5
| ASW | 17.5 | 54.4 | 28.1
| CHB | 6.6 | 38.0 | 55.5
| CHD | 3.7 | 37.6 | 58.7
| GIH | 53.5 | 37.6 | 8.9
| LWK | 23.6 | 42.7 | 33.6
| MEX | 15.5 | 53.4 | 31.0
| MKK | 30.1 | 43.6 | 26.3
| TSI | 45.1 | 41.2 | 13.7
| HapMapRevision=28
}}{{PMID|17053149}} In a Swiss cohort: "Carriers of KIBRA rs17070145 T allele had 24% better free recall performance 5 min after word presentation (P = 0.000004) and 19% better free recall performance 24 hours after word presentation (P = 0.0008) than did noncarriers."
In a US cohort: "T allele carriers had significantly better [[memory]] scores than non-carriers in the Buschke's Selective Reminding Test (SRT). Performance on another episodic memory task, the Rey Auditory Verbal Learning Test (AVLT), was also significantly different between allele groups."
In another Swiss cohort, with a visual episodic memory task: "T allele carriers also performed significantly better than did noncarriers in this population."
"Functional magnetic resonance imaging detected KIBRA allele-dependent differences in hippocampal activations during memory retrieval."

{{PMID|17353070}} Replication in a healthy elderly cohort.

{{omim
|id=610533
|desc=WW, C2, AND COILED-COIL DOMAIN-CONTAINING 1; WWC1
|rsnum=17070145
}}
{{PMID Auto
|PMID=19606085
|Title=Cognitive Flexibility is Associated with KIBRA Variant and Modulated by Recent Tobacco Use
|OA=1
}}

{{PMID Auto
|PMID=20150879
|Title=Single nucleotide polymorphism of the KIBRA gene in recurrent depressive disorders
}}

{{PMID Auto
|PMID=20185150
|Title=Evidence of association of KIBRA genotype with episodic memory in families of psychotic patients and controls
}}

{{PMID Auto
|PMID=20509760
|Title=Association study of KIBRA gene with memory performance in a Japanese population
}}
{{PMID Auto
|PMID=21185624
|Title=Association of common KIBRA variants with episodic memory and AD risk
|OA=1
}}

{{omim
|id=610533
|rsnum=17070145
|variant=0001
}}

{{PMID Auto
|PMID=21976506
|Title=KIBRA Polymorphism Is Related to Enhanced Memory and Elevated Hippocampal Processing
}}

{{PMID Auto
|PMID=22457502
|Title=Interaction of BDNF and COMT Polymorphisms on Paired-Associative Stimulation-Induced Cortical Plasticity
}}

{{PMID|17707552}} Age-dependent association of KIBRA genetic variation and Alzheimer's disease risk.

{{PMID|17903297|OA=1
}} Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study.

{{PMID|18194457}} KIBRA genetic polymorphism influences episodic memory in later life, but does not increase the risk of mild cognitive impairment.

{{PMID|18205171}} Failure to replicate effect of Kibra on human memory in two large cohorts of European origin.

{{PMID|18789830|OA=1
}} Evidence for an association between KIBRA and late-onset Alzheimer's disease.

{{PMID|19397951}} Association of KIBRA and memory.

{{PMID|20184726|OA=1
}} Caspase-1 genetic variation is not associated with Alzheimer's disease risk.

{{PMID|20552044|OA=1
}} KIBRA: A New Gateway to Learning and Memory?

{{PMID|21346737|OA=1
}} Impact of common KIBRA allele on human cognitive functions.

{{PMID|21643791}} The role of memory-related gene polymorphisms, KIBRA and CLSTN2, on replicate memory assessment in the elderly.

{{PMID Auto
|PMID=23266749
|Title=KIBRA gene variants are associated with synchronization within the default-mode and executive control networks
}}

{{PMID Auto
|PMID=23926262
|Title=KIBRA Polymorphism Is Associated with Individual Differences in Hippocampal Subregions: Evidence from Anatomical Segmentation using High-Resolution MRI
}}

{{PMID Auto
|PMID=22794909
|Title=Association of KIBRA rs17070145 polymorphism and episodic memory in individuals with severe TBI.
}}

{{PMID Auto
|PMID=23065961
|Title=Association of KIBRA with episodic and working memory: a meta-analysis.
}}

{{PMID Auto
|PMID=23733450
|Title=Aging and KIBRA/WWC1 genotype affect spatial memory processes in a virtual navigation task.
}}

{{PMID Auto
|PMID=23778582
|Title=Common exonic missense variants in the C2 domain of the human KIBRA protein modify lipid binding and cognitive performance.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}