{{Rsnum
|rsid=17107315
|Gene=SPINK1
|Chromosome=5
|position=147828115
|Orientation=plus
|ReferenceAllele=A
|MissenseAllele=G
|GMAF=0.005969
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=SPINK1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 0.0 | 0.9 | 99.1
| HCB | 0.0 | 1.5 | 98.5
| JPT | 0.0 | 3.5 | 96.5
| YRI | 0.0 | 0.0 | 100.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 0.0 | 1.5 | 98.5
| CHD | 0.0 | 0.9 | 99.1
| GIH | 0.0 | 3.0 | 97.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 2.0 | 98.0
| HapMapRevision=28
}}
{{omim
|desc=PANCREATITIS, CHRONIC, SUSCEPTIBILITY TO
|id=167790
|rsnum=17107315
|variant=0001
}}

{{PharmGKB
|RSID=rs17107315
|Name_s=SPINK1:112 C>T
|Gene_s=SPINK1
|Feature=
|Evidence=PubMed ID:15238770
|Annotation=This variant is associated with risk of pancreatitits for HIV-infected individuals.
|Drugs=
|Drug Classes=
|Diseases=HIV; HIV Infections; Pancreatitis
|Curation Level=Curated
|PharmGKB Accession ID=PA162360002
}}

{{PharmGKB
|RSID=rs17107315
|Name_s=SPINK1: N34S
|Gene_s=SPINK1
|Feature=
|Evidence=PubMed ID:15764155
|Annotation=This SNP is significantly associated with an increased risk of chronic pancreatitis.
|Drugs=
|Drug Classes=
|Diseases=Pancreatitis
|Curation Level=Curated
|PharmGKB Accession ID=PA162190477
}}

{{ClinVar
|rsid=17107315
|Reversed=1
|FwdREF=A
|FwdALT=G
|REF=T
|ALT=C
|RSPOS=147207678
|CHROM=5
|GMAF=0.006
|dbSNPBuildID=123
|SSR=0
|SAO=1
|VP=0x050268000000040517110100
|GENEINFO=SPINK1:6690
|GENE_NAME=SPINK1
|GENE_ID=6690
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000005.9:g.147207678T>C
|CLNSRC=OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=167790.0001
|CLNSIG=255
|CLNCUI=C1969419; C1842402
|CLNDBN=Pancreatitis, chronic, susceptibility to; Tropical calcific pancreatitis; Fibrocalculous pancreatic diabetes, susceptibility to
|Disease=Pancreatitis; Tropical calcific pancreatitis; Fibrocalculous pancreatic diabetes
|CLNACC=RCV000014768.2; RCV000014769.24; RCV000014770.1
|Tags=RV;PM;PMC;S3D;VLD;HD;GNO;KGPhase1;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.994; 0.005969
|CLNDSDB=MedGen; MedGen:OMIM:Orphanet
|CLNDSDBID=C1969419; C1842402:608189:103918
|COMMON=1
}}

{{PMID Auto
|PMID=17204
|Title=Characterization of longstanding specific unresponsiveness in adult recipients of strongly histoincompatible hemopoietic stem cells.
}}

{{PMID Auto
|PMID=10691414
|Title=Mutational analysis of the human pancreatic secretory trypsin inhibitor (PSTI) gene in hereditary and sporadic chronic pancreatitis.
|OA=1
}}

{{PMID Auto
|PMID=10835640
|Title=Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis.
}}

{{PMID Auto
|PMID=16885867
|Title=Estimation of the prevalence and incidence of chronic pancreatitis and its complications.
}}

{{PMID Auto
|PMID=18286680
|Title=Role of genetic disorders in acute recurrent pancreatitis.
|OA=1
}}

{{PMID Auto
|PMID=19453252
|Title=Chronic pancreatitis: genetics and pathogenesis.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}