{{Rsnum
|rsid = 17110563
|Gene = TPH2
|Orientation=plus
|ReferenceAllele=C
|MissenseAllele=T
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Chromosome=12
|position=71972526
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene_s=TPH2
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 98.2 | 1.8 | 0.0
| HCB | 99.3 | 0.7 | 0.0
| JPT | 99.1 | 0.9 | 0.0
| YRI | 0.0 | 0.0 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 99.3 | 0.7 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 98.2 | 1.8 | 0.0
| MEX | 98.2 | 1.8 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[[rs17110563]], also known as Pro206Ser, is a SNP in the [[TPH2]] gene. The minor allele of this SNP yielded an odds ratio of 4.8 (CI:1.6-14.8) for increased risk for [[bipolar disorder]] in a study of 883 Russian patients.{{PMID|17905754}}

{{ neighbor
| rsid = 7963720
| distance = 120
}}

{{omim
|id=607478
|desc=TRYPTOPHAN HYDROXYLASE 2; TPH2
|rsnum=17110563
}}

{{PharmGKB
|RSID=rs17110563
|Name_s=TPH2: P206S
|Gene_s=TPH2
|Feature=
|Evidence=PubMed ID:16203956; PubMed ID:17905754
|Annotation=This variant has been reported to be associated with unipolar and bipolar depression in different populations.
|Drugs=
|Drug Classes=
|Diseases=Depression
|Curation Level=Curated
|PharmGKB Accession ID=PA162190494
}}

{{omim
|id=607478
|rsnum=17110563
|variant=0003
}}

{{ClinVar
|rsid=17110563
|Reversed=0
|FwdREF=C
|FwdALT=T
|REF=C
|ALT=T
|RSPOS=72366306
|CHROM=12
|dbSNPBuildID=123
|SSR=0
|SAO=1
|VP=0x050268000000040503110100
|GENEINFO=TPH2:121278
|GENE_NAME=TPH2
|GENE_ID=121278
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000012.11:g.72366306C>T
|CLNORIGIN=1
|CLNSIG=255
|Tags=PM;PMC;S3D;VLD;HD;GNO;OTHERKG;PH3;LSD;OM
|CLNACC=RCV000003314.1
|CLNDBN=Bipolar affective disorder, susceptibility to
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=607478.0003
|Disease=Bipolar affective disorder
}}

{{PMID Auto
|PMID=18797398
|Title=Investigation of the tryptophan hydroxylase 2 gene in bipolar I disorder in the Romanian population.
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}