{{Rsnum
|rsid=17110690
|Gene=TPH2
|Chromosome=12
|position=72014217
|Orientation=plus
|GMAF=0.2172
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=TPH2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 4.4 | 34.5 | 61.1
| HCB | 5.8 | 43.8 | 50.4
| JPT | 7.1 | 41.6 | 51.3
| YRI | 2.0 | 17.7 | 80.3
| ASW | 0.0 | 17.5 | 82.5
| CHB | 5.8 | 43.8 | 50.4
| CHD | 11.0 | 51.4 | 37.6
| GIH | 4.0 | 22.8 | 73.3
| LWK | 0.0 | 13.6 | 86.4
| MEX | 0.0 | 34.5 | 65.5
| MKK | 1.9 | 29.5 | 68.6
| TSI | 2.9 | 34.3 | 62.7
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs17110690
|Name_s=
|Gene_s=TPH2
|Feature=
|Evidence=PubMed ID:19125159
|Annotation=In a case-control study consisting of 998 patients with recurrent unipolar depression (RUD) and 1023 psychiatric healthy controls this variant in an intron region of the TPH2 gene showed significant association with the rate of metabolic syndrome.
|Drugs=
|Drug Classes=
|Diseases=Depression; metabolic syndrome
|Curation Level=Curated
|PharmGKB Accession ID=PA163367830
}}

{{PharmGKB
|RSID=rs17110690
|Name_s=
|Gene_s=TPH2
|Feature=
|Evidence=PubMed ID:19125159
|Annotation=A case-control study consisting of 988 patients with recurrent unipolar depression and 1023 psychiatric healthy controls, showed a significant genetic association of rs17110690 polymorphism in TPH2 and the occurrence of metabolic syndrome (MetS) in depressed patients. The study linked risk-genotypes and risk-haplotypes for MetS to lower TPH2 mRNA expression and to lower 5-hydroxyindoleacetic acid levels in cerebrospinal fluid.
|Drugs=
|Drug Classes=
|Diseases=metabolic syndrome
|Curation Level=Curated
|PharmGKB Accession ID=PA162411189
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs17110690
|overall_frequency_n=12
|overall_frequency_d=126
|overall_frequency=0.0952381
|n_genomes=11
|n_genomes_annotated=0
|n_haplomes=12
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}