{{Rsnum
|rsid=17145738
|Gene=TBL2
|Chromosome=7
|position=73568544
|Orientation=plus
|GMAF=0.09688
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=TBL2
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 77.9 | 20.4 | 1.8
| HCB | 73.0 | 26.3 | 0.7
| JPT | 81.4 | 16.8 | 1.8
| YRI | 82.3 | 17.0 | 0.7
| ASW | 87.7 | 12.3 | 0.0
| CHB | 73.0 | 26.3 | 0.7
| CHD | 82.6 | 17.4 | 0.0
| GIH | 88.1 | 11.9 | 0.0
| LWK | 83.5 | 16.5 | 0.0
| MEX | 82.8 | 17.2 | 0.0
| MKK | 80.1 | 18.6 | 1.3
| TSI | 84.3 | 14.7 | 1.0
| HapMapRevision=28
}}{{PMID|18596051}} [[rs17145738]] influences severe [[hypertriglyceridemia]]. 132 patients of European ancestry with severe HTG (fasting plasma TG>10 mmol/L), and 351 matched normolipidemic controls

{{GWAS Summary
|SNP=rs17145738
|PubMedID=18193043
|Condition=Triglycerides
|Gene=MLXIPL
|Risk Allele=C
|pValue=2.00E-012
|OR=8.21
|95CI=NR) mg/dl highe
}}

{{PMID Auto GWAS
|PMID=18193044
|Trait=Triglycerides
|Title=Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
|RiskAllele=T
|Pval=7.0000000000000001E-22
|OR=0.14
|ORtxt=[0.25-0.53] % SD lower
|OA=1
}}

{{PharmGKB
|RSID=rs17145738
|Name_s=
|Gene_s=TBL2
|Feature=
|Evidence=PubMed ID:18193043; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Newly identified loci that influence lipid concentrations and risk of coronary artery disease (Initial Sample Size: 8,684 individuals; Replication Sample Size: 5,312-9,707 individuals; Risk Allele: rs17145738-C). This variant is associated with triglyceride levels.
|Drugs=
|Drug Classes=
|Diseases=Cardiovascular Diseases; Coronary Disease
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356707
}}

{{PMID Auto
|PMID=19656773
|Title=A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia
|OA=1
}}

{{PharmGKB
|RSID=rs17145738
|Name_s=
|Gene_s=TBL2
|Feature=
|Evidence=PubMed ID:18193044; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans (Initial Sample Size: 2,758 individuals; Replication Sample Size: 18,544 individuals; Risk Allele: rs17145738-T). This variant is associated with triglyceride levels.
|Drugs=
|Drug Classes=
|Diseases=Cardiovascular Diseases; Coronary Disease
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356718
}}

{{PMID Auto
|PMID=21149302
|Title=Effects of genetic variants on lipid parameters and dyslipidemia in a Chinese population
|OA=1
}}

{{PMID Auto GWAS
|PMID=20686565
|Trait=None
|Title=Biological, clinical and population relevance of 95 loci for blood lipids.
|RiskAllele=T
|Pval=1E-9
|OR=0.5700
|ORtxt=None
|OA=1
}}

{{PMID Auto
|PMID=18852197
|Title=Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.
|OA=1
}}

{{PMID Auto
|PMID=19060910
|Title=Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
|OA=1
}}

{{PMID Auto
|PMID=19185284
|Title=Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study.
|OA=1
}}

{{PMID Auto
|PMID=19197348
|Title=Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
|OA=1
}}

{{PMID Auto
|PMID=19299407
|Title=Replication of genetic associations with plasma lipoprotein traits in a multiethnic sample.
|OA=1
}}

{{PMID Auto
|PMID=19435741
|Title=Common lipid-altering gene variants are associated with therapeutic intervention thresholds of lipid levels in older people.
|OA=1
}}

{{PMID Auto
|PMID=20017967
|Title=Genome-wide association analyses of North American Rheumatoid Arthritis Consortium and Framingham Heart Study data utilizing genome-wide linkage results.
|OA=1
}}

{{PMID Auto
|PMID=20158509
|Title=Triglyceride level modifying functional variants of GALTN2 and MLXIPL in patients with ischaemic stroke.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs17145738
|overall_frequency_n=14
|overall_frequency_d=128
|overall_frequency=0.109375
|n_genomes=9
|n_genomes_annotated=0
|n_haplomes=9
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=24160749
|Title=Association of the MLXIPL/TBL2 rs17145738 SNP and serum lipid levels in the Guangxi Mulao and Han populations
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Affy500k}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}