{{Rsnum
|rsid=1718119
|Gene=P2RX7
|Chromosome=12
|position=121177300
|Orientation=minus
|GMAF=0.3081
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=P2RX7
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 30.1 | 51.3 | 18.6
| HCB | 80.0 | 20.0 | 0.0
| JPT | 61.6 | 33.9 | 4.5
| YRI | 26.9 | 49.7 | 23.4
| ASW | 26.3 | 52.6 | 21.1
| CHB | 80.0 | 20.0 | 0.0
| CHD | 81.7 | 17.4 | 0.9
| GIH | 39.4 | 51.5 | 9.1
| LWK | 29.4 | 51.4 | 19.3
| MEX | 61.4 | 36.8 | 1.8
| MKK | 23.1 | 48.7 | 28.2
| TSI | 43.1 | 41.2 | 15.7
| HapMapRevision=28
}}{{PMID Auto
|PMID=20535134
|Title=Evidence for associations between the purinergic receptor P2X(7) (P2RX7) and toxoplasmosis
|OA=1
}}

{{PMID Auto
|PMID=17197037
|Title=Association of polymorphisms in P2RX7 and CaMKKb with anxiety disorders.
}}

{{PMID Auto
|PMID=19319666
|Title=Genetics of the P2X7 receptor and human disease.
|OA=1
}}

{{PMID Auto
|PMID=19838818
|Title=Identification and characterization of a novel variant of the human P2X(7) receptor resulting in gain of function.
|OA=1
}}

{{PMID Auto
|PMID=20360457
|Title=Two haplotypes of the P2X(7) receptor containing the Ala-348 to Thr polymorphism exhibit a gain-of-function effect and enhanced interleukin-1beta secretion.
}}

{{GET Evidence
|gene=P2RX7
|aa_change=Ala348Thr
|aa_change_short=A348T
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1718119
|overall_frequency_n=4486
|overall_frequency_d=10758
|overall_frequency=0.416992
|n_genomes=36
|n_genomes_annotated=0
|n_haplomes=44
|n_articles=0
|n_articles_annotated=0
|nblosum100=1
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=22661222
|Title=P2X7 receptor activation mediates organic cation uptake into human myeloid leukaemic KG-1 cells.
|OA=1
}}

{{PMID Auto
|PMID=22776862
|Title=Association of P2X7 receptor polymorphisms with bone mineral density and osteoporosis risk in a cohort of Dutch fracture patients.
|OA=1
}}

{{PMID Auto
|PMID=23435013
|Title=Association of P2X7R gene polymorphisms with systemic lupus erythematosus in a Chinese population.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}