{{Rsnum
|rsid=17221417
|Gene=NOD2
|Chromosome=16
|position=50705671
|Orientation=plus
|GMAF=0.1451
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=NOD2
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 37.2 | 55.8 | 7.1
| HCB | 99.3 | 0.7 | 0.0
| JPT | 99.1 | 0.9 | 0.0
| YRI | 97.3 | 2.7 | 0.0
| ASW | 77.2 | 17.5 | 5.3
| CHB | 99.3 | 0.7 | 0.0
| CHD | 99.1 | 0.9 | 0.0
| GIH | 82.2 | 16.8 | 1.0
| LWK | 93.5 | 6.5 | 0.0
| MEX | 65.5 | 32.8 | 1.7
| MKK | 71.2 | 26.3 | 2.6
| TSI | 55.9 | 37.3 | 6.9
| HapMapRevision=28
}}
[[rs17221417]] has been reported in a large study to be associated with [[Crohn's disease]].

The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.29 (CI 1.13-1.46), and for homozygotes, 1.92 (CI 1.58-2.34). {{PMID|17554300|OA=1
}}

{{omim
|desc=NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN PROTEIN 2; NOD2
|id=605956
|rsnum=17221417
}}

{{PMID|18224312|OA=1
}} Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.

{{PMID|18843111|OA=1
}} Individual disease risk and multimetric analysis of Crohn disease.

{{PMID|18853133|OA=1
}} Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs17221417
|overall_frequency_n=24
|overall_frequency_d=128
|overall_frequency=0.1875
|n_genomes=17
|n_genomes_annotated=0
|n_haplomes=21
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}