{{Rsnum
|rsid=17222723
|Gene=ABCC2
|Chromosome=10
|position=101595996
|Orientation=plus
|GMAF=0.0427
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=132
|geno1=(A;A)
|geno2=(A;T)
|geno3=(T;T)
}}
{{PharmGKB
|RSID=rs17222723
|Name_s=ABCC2 rs8187694, MRP2 Val1188Glu
|Gene_s=ABCC2
|Feature=Exon/NonSyn
|Evidence=PubMed ID:16330681
|Annotation=Risk or phenotype-associated allele: A. Phenotype: This SNP was part of a haplotype associated with acute cardiotoxicity in response to doxorubicin. Study size: 1697. Study population/ethnicity: Participants of the German non-Hodgkin lymphoma study. Significance metric(s): OR = 2.3; 95% CI, 1.0 to 5.4. Type of association: PD; ADR; TOX.
|Drugs=doxorubicin
|Drug Classes=
|Diseases=Arrhythmias, Cardiac; Cardiomyopathies; Drug Toxicity; Lymphoma, Non-Hodgkin
|Curation Level=Curated
|PharmGKB Accession ID=PA165291813
}}

{{ population diversity
| geno1 = (A;T)
| geno2 = (T;T)
| geno3 = 
| CEU | 13.3 | 86.7 | 0
| CHB | 0.0 | 100.0 | 0
| JPT | 0.0 | 100.0 | 0
| YRI | 11.7 | 88.3 | 0
}}

{{PMID Auto
|PMID=17997497
|Title=Association of the multidrug-resistance-associated protein gene (ABCC2) variants with intrahepatic cholestasis of pregnancy.
}}

{{PMID Auto
|PMID=18176959
|Title=Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pump.
|OA=1
}}

{{PMID Auto
|PMID=18395921
|Title=Role of ABCC2 common variants in intrahepatic cholestasis of pregnancy.
|OA=1
}}

{{PMID Auto
|PMID=18926681
|Title=Polymorphisms of MRP2 (ABCC2) are associated with susceptibility to nonalcoholic fatty liver disease.
}}

{{GET Evidence
|gene=ABCC2
|aa_change=Val1188Glu
|aa_change_short=V1188E
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs17222723
|overall_frequency_n=667
|overall_frequency_d=10758
|overall_frequency=0.0620004
|n_genomes=10
|n_genomes_annotated=0
|n_haplomes=10
|n_articles=1
|n_articles_annotated=1
|gene_in_genetests=Y
|in_pharmgkb=Y
|genetests_testable=Y
|nblosum100=5
|autoscore=3
|webscore=N
|n_web_uneval=8
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}