{{Rsnum
|rsid=17228212
|Gene=SMAD3
|Chromosome=15
|position=67166301
|Orientation=plus
|GMAF=0.1561
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=SMAD3
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 12.5 | 42.9 | 44.6
| HCB | 0.0 | 1.5 | 98.5
| JPT | 0.0 | 0.0 | 100.0
| YRI | 1.4 | 19.2 | 79.5
| ASW | 0.0 | 22.8 | 77.2
| CHB | 0.0 | 1.5 | 98.5
| CHD | 0.0 | 0.0 | 0.0
| GIH | 4.0 | 13.9 | 82.2
| LWK | 3.6 | 22.7 | 73.6
| MEX | 1.7 | 12.1 | 86.2
| MKK | 3.8 | 20.5 | 75.6
| TSI | 9.8 | 34.3 | 55.9
| HapMapRevision=28
}}[[rs17228212]] is a SNP found to be associated with [[heart disease]] by the German MI (Myocardial infarction) Family Study group in two populations. The odds ratio per allele is 1.26 (CI: 1.11-1.44, p=0.0178).{{PMID|17634449|OA=1
}}

{{PMID|18979498|OA=1
}} [[rs599839]], [[rs4970834]] and [[rs17228212]] associated with non-HDL [[cholesterol]]

{{PMID Auto
|PMID=18780302
|Title=Association studies of 22 candidate SNPs with late-onset Alzheimer's disease.
|OA=1
}}

{{PMID Auto
|PMID=19198609
|Title=Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.
|OA=1
}}

{{PMID Auto
|PMID=19750184
|Title=Genome-wide association studies for atherosclerotic vascular disease and its risk factors.
|OA=1
}}

{{PMID Auto
|PMID=19956433
|Title=Genetics of coronary artery disease: focus on genome-wide association studies.
|OA=1
}}

{{PMID Auto
|PMID=20017983
|Title=Evaluation of population impact of candidate polymorphisms for coronary heart disease in the Framingham Heart Study Offspring Cohort.
|OA=1
}}

{{PMID Auto
|PMID=20098575
|Title=Genetics and cardiovascular disease: Design and development of a DNA biobank.
|OA=1
}}

{{PMID Auto
|PMID=21804106
|Title=Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs17228212
|overall_frequency_n=24
|overall_frequency_d=128
|overall_frequency=0.1875
|n_genomes=16
|n_genomes_annotated=0
|n_haplomes=21
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}