{{Rsnum
|rsid=17244841
|Gene=HMGCR
|Chromosome=5
|position=75347030
|Orientation=plus
|GMAF=0.03811
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;T)
|geno3=(T;T)
|Gene_s=HMGCR
}}[[rs17244841]], also known as SNP 12, is located in the HMG-CoA reductase [[HMGCR]] gene. The protein encoded by this gene is the target for drugs designed to inhibit its action, in order to lower cholesterol levels. SNPs in the [[HMGCR]] gene may affect how well such drugs (typically [[statins]]) work.

In a study of ~1,500 patients treated with 40mg/d of [[pravastatin]], [[rs17244841]](A;T) heterozgyotes had a mean decrease in total cholesterol of â€“32.8 mg/dL (â€“0.85 mmol/L), while the mean change for [[rs17244841]](A;A) homozygotes was â€“42.0 mg/dL (â€“1.09 mmol/L), a reduction in overall efficacy of 21.8% (absolute difference, 9.2 mg/dL, CI: 3.8-14.6 mg/dL, p=.001). The drop in total cholesterol was almost completely due to the decrease in LDL cholesterol, as there was no significant difference in the change in HDL cholesterol with [[pravastatin]] between genotypes.{{PMID|15199031}}

This SNP is in tight linkage (r<sup>2</sup>>0.90) with another, [[rs17238540]], so practically speaking, they are equivalent to each other.

{{PharmGKB
|RSID=rs17244841
|Name_s=HMGCR:SNP 12
|Gene_s=HMGCR
|Feature=Intron
|Evidence=Web Resource:http://www.pharmgkb.org/search/annotatedGene/hmgcr/variant.jsp#ImportantVariantInformationforHMGCR-SNP12
|Annotation=Associated with total cholesterol and LDL-cholesterol levels.
|Drugs=pravastatin
|Drug Classes=
|Diseases=
|Curation Level=In-Depth
|PharmGKB Accession ID=PA161145167
}}

{{PMID Auto
|PMID=18559695
|Title=Alternative splicing of 3-hydroxy-3-methylglutaryl coenzyme A reductase is associated with plasma low-density lipoprotein cholesterol response to simvastatin.
|OA=1
}}

{{PMID Auto
|PMID=20005478
|Title=The role of HMGCR alternative splicing in statin efficacy.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs17244841
|overall_frequency_n=3
|overall_frequency_d=92
|overall_frequency=0.0326087
|n_genomes=2
|n_genomes_annotated=0
|n_haplomes=2
|n_articles=0
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}