{{Rsnum
|rsid=1726866
|Gene=TAS2R38
|Chromosome=7
|position=141972905
|Orientation=minus
|ReferenceAllele=T
|MissenseAllele=C
|GMAF=0.4082
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=MGAM,TAS2R38
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 19.5 | 46.9 | 33.6
| HCB | 46.7 | 41.6 | 11.7
| JPT | 34.8 | 45.5 | 19.6
| YRI | 43.8 | 49.3 | 6.9
| ASW | 42.1 | 52.6 | 5.3
| CHB | 46.7 | 41.6 | 11.7
| CHD | 50.5 | 42.2 | 7.3
| GIH | 16.8 | 51.5 | 31.7
| LWK | 49.1 | 42.7 | 8.2
| MEX | 39.7 | 44.8 | 15.5
| MKK | 38.5 | 50.0 | 11.5
| TSI | 32.4 | 45.1 | 22.5
| HapMapRevision=28
}}[[rs1726866]] is one of three SNPs that form the main haplotypes behind the ability to perceive as bitter the [[taste]] of the compound phenylthiocarbamide (PTC) and similar molecules in foods (like cabbage and raw broccoli) or drinks (like [[coffee]] and dark beers).

The [[rs1726866(C)]] allele is the "tasting" allele, and it is dominant to the "non-tasting" allele [[rs1726866(T)]], so having one copy is enough to have the bitter tasting ability. If you are a "taster", you're also likely to carry at least one [[rs713598(G)]] and one [[rs10246939(C)]] allele since, along with [[rs1726866(C)]], these three SNPs form the most common tasting haplotype. If you lack these alleles, you're quite likely (~80%) to be a non-taster of bitterness, meaning that foods that may taste bitter to others taste far less bitter to you.{{PMID|12595690}} 

{{PMID|19782709|OA=1
}} (C;C) women showed a lower tendency to overeat. (T;T) women showed a greater tendency to overeat.

{{ neighbor
| rsid = 10246939
| distance = 101
}}

{{omim
|id=607751
|desc=TASTE RECEPTOR, TYPE 2, MEMBER 38; TAS2R38
|rsnum=1726866
}}

{{omim
|id=607751
|rsnum=1726866
|variant=0002
}}

{{ClinVar
|rsid=1726866
|Reversed=1
|FwdREF=C
|FwdALT=T
|REF=G
|ALT=A
|RSPOS=141672705
|CHROM=7
|GMAF=0.4084
|dbSNPBuildID=89
|SSR=0
|SAO=1
|VP=0x05016800000017051f110101
|WGT=0
|VC=SNV
|CLNALLE=0
|CLNHGVS=NC_000007.13:g.141672705G\x3d
|CLNSIG=6
|Tags=RV;PM;PMC;SLO;VLD;G5A;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.5918; 0.4082
|CLNACC=RCV000003039.1
|CLNDBN=Phenylthiocarbamide tasting
|CLNDSDB=MedGen
|CLNDSDBID=C1868398
|CLNORIGIN=1
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=607751.0002
|COMMON=1
|Disease=Phenylthiocarbamide tasting
|GENEINFO=TAS2R38:5726
|GENE_ID=5726
|GENE_NAME=TAS2R38
}}

{{PMID Auto
|PMID=15883422
|Title=TAS2R38 (phenylthiocarbamide) haplotypes, coronary heart disease traits, and eating behavior in the British Women's Heart and Health Study.
}}

{{PMID Auto
|PMID=18248681
|Title=Prevalence of common disease-associated variants in Asian Indians.
|OA=1
}}

{{PMID Auto
|PMID=18834969
|Title=A combinatorial approach to detecting gene-gene and gene-environment interactions in family studies.
|OA=1
}}

{{PMID Auto
|PMID=19092995
|Title=Bitter taste receptors influence glucose homeostasis.
|OA=1
}}

{{PMID Auto
|PMID=19779476
|Title=Sex differences in the effects of inherited bitter thiourea sensitivity on body weight in 4-6-year-old children.
|OA=1
}}

{{GET Evidence
|gene=TAS2R38
|aa_change=Ala262Val
|aa_change_short=A262V
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1726866
|overall_frequency_n=5093
|overall_frequency_d=10758
|overall_frequency=0.473415
|n_genomes=37
|n_genomes_annotated=0
|n_haplomes=48
|n_articles=0
|n_articles_annotated=0
|qualityscore_in_silico=2
|qualitycomment_in_silico=Y
|pph2_score=0.01
|genetests_testable=Y
|genetests_reviewed=Y
|nblosum100=2
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=24083639
|Title=Variations in Bitter-Taste Receptor Genes, Dietary Intake, and Colorectal Adenoma Risk
}}

{{PMID Auto
|PMID=23133589
|Title=Bitter taste receptor polymorphisms and human aging.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}