{{Rsnum
|rsid=17271305
|Gene=VPS13C
|Chromosome=15
|position=62040781
|Orientation=plus
|GMAF=0.2599
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=VPS13C
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 35.4 | 46.2 | 18.5
| HCB | 80.0 | 20.0 | 0.0
| JPT | 72.7 | 25.0 | 2.3
| YRI | 88.9 | 11.1 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 80.0 | 20.0 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=20081857
|Trait=Two-hour glucose challenge
|Title=Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
|RiskAllele=G
|Pval=1E-7
|OR=0.06
|ORtxt=[0.04-0.08 mmol/L increase
|OA=1
}}

{{PharmGKB
|RSID=rs17271305
|Name_s=
|Gene_s=VPS13C
|Feature=
|Evidence=PubMed ID:20081857
|Annotation=Risk or phenotype-associated allele: G . Phenotype: In a meta-analysis of nine genome-wide association studies (n = 15,234 nondiabetic individuals) and a follow-up of 29 independent loci (n = 6,958-30,620), this SNP was found to be associated with 2-h glucose level (a clinical measure of glucose tolerance). Effect (s.e.m.) = 0.06(0.01) mmol/l per G allele. Study size/population/ethnicity: 15,234 plus 6,958-30,620 nondiabetic individuals of European descent. Significance metric(s): p = 4.11 x 10(-8). Type of association: CO;GN.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus, Type 2
|Curation Level=Curated
|PharmGKB Accession ID=PA165281982
}}
{{PMID Auto
|PMID=21249489
|Title=The diabetogenic VPS13C/C2CD4A/C2CD4B rs7172432 variant impairs glucose-stimulated insulin response in 5,722 non-diabetic Danish individuals
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs17271305
|overall_frequency_n=33
|overall_frequency_d=126
|overall_frequency=0.261905
|n_genomes=22
|n_genomes_annotated=0
|n_haplomes=27
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}