{{Rsnum
|rsid=17321515
|Chromosome=8
|position=125474167
|Orientation=plus
|GMAF=0.4917
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 31.0 | 52.2 | 16.8
| HCB | 14.0 | 50.0 | 36.0
| JPT | 21.2 | 52.2 | 26.5
| YRI | 23.8 | 52.4 | 23.8
| ASW | 21.4 | 42.9 | 35.7
| CHB | 14.0 | 50.0 | 36.0
| CHD | 17.6 | 45.4 | 37.0
| GIH | 37.6 | 46.5 | 15.8
| LWK | 19.3 | 45.9 | 34.9
| MEX | 40.4 | 50.9 | 8.8
| MKK | 26.5 | 51.6 | 21.9
| TSI | 22.5 | 51.0 | 26.5
| HapMapRevision=28
}}{{PMID|18596051}} [[rs17321515]] influences severe [[hypertriglyceridemia]]. 132 patients of European ancestry with severe HTG (fasting plasma TG>10 mmol/L), and 351 matched normolipidemic controls

{{GWAS Summary
|SNP=rs17321515
|PubMedID=18193043
|Condition=Triglycerides
|Gene=TRIB1
|Risk Allele=A
|pValue=7.00E-013
|OR=6.42
|95CI=NR) mg/dl highe
}}

{{PMID Auto GWAS
|PMID=18193044
|Trait=Triglycerides
|Title=Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
|RiskAllele=A
|Pval=4.0000000000000003E-17
|OR=0.08
|ORtxt=[0.06-0.10] % SD lower
|OA=1
}}

{{PharmGKB
|RSID=rs17321515
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18193043; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Newly identified loci that influence lipid concentrations and risk of coronary artery disease (Initial Sample Size: 8,684 individuals; Replication Sample Size: 5,312-9,707 individuals; Risk Allele: rs17321515-A). This variant is associated with triglyceride levels.
|Drugs=
|Drug Classes=
|Diseases=Cardiovascular Diseases; Coronary Disease
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356708
}}

{{PMID Auto
|PMID=19656773
|Title=A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia
|OA=1
}}

{{PMID Auto
|PMID=20692138
|Title=Polymorphism at the TRIB1 gene modulates plasma lipid levels: Insight from the spanish familial hypercholesterolemia cohort study
}}

{{PharmGKB
|RSID=rs17321515
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18193044; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans (Initial Sample Size: 2,758 individuals; Replication Sample Size: 18,544 individuals; Risk Allele: rs17321515-A). This variant is associated with triglyceride levels.
|Drugs=
|Drug Classes=
|Diseases=Cardiovascular Diseases; Coronary Disease
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356719
}}

{{PMID Auto
|PMID=22145581
|Title=Association of the TRIB1 tribbles homolog 1 gene rs17321515 A&gt;G polymorphism and serum lipid levels in the Mulao and Han populations
|OA=1
}}

{{PMID Auto
|PMID=18852197
|Title=Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.
|OA=1
}}

{{PMID Auto
|PMID=18987386
|Title=Polymorphisms at newly identified lipid-associated loci are associated with blood lipids and cardiovascular disease in an Asian Malay population.
}}

{{PMID Auto
|PMID=19060910
|Title=Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
|OA=1
}}

{{PMID Auto
|PMID=19060911
|Title=Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
|OA=1
}}

{{PMID Auto
|PMID=19185284
|Title=Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study.
|OA=1
}}

{{PMID Auto
|PMID=19197348
|Title=Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
|OA=1
}}

{{PMID Auto
|PMID=19304782
|Title=Admixture mapping of quantitative trait loci for blood lipids in African-Americans.
|OA=1
}}

{{PMID Auto
|PMID=19435741
|Title=Common lipid-altering gene variants are associated with therapeutic intervention thresholds of lipid levels in older people.
|OA=1
}}

{{PMID Auto
|PMID=20972250
|Title=Genetic loci associated with lipid concentrations and cardiovascular risk factors in the Korean population.
}}

{{PMID Auto
|PMID=21691831
|Title=Triglyceride level-influencing functional variants of the ANGPTL3, CILP2, and TRIB1 loci in ischemic stroke.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs17321515
|overall_frequency_n=54
|overall_frequency_d=128
|overall_frequency=0.421875
|n_genomes=39
|n_genomes_annotated=0
|n_haplomes=46
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23596713
|Title=[SNP of rs17321515 homologous with Trib1 in Han population and its correlation with blood lipid]
}}

{{PMID Auto GWAS
  |PMID=24386095
  |Trait=Lipid traits
  |Title=A genome wide association study identifies common variants associated with lipid levels in the Chinese population.
  |RiskAllele=A
  |Pval=8E-7
  |OR=.07
  |ORtxt=mmol/L increase
  }}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Affy500k}}
{{on chip | HumanOmni1Quad}}